Exploring the Mechanism of Feiyanning formula and its extract Apigenin Against EGFR-TKIs Resistance in Non-Small Cell Lung cancer Based on UPLC-HRMS and Experimental Validation [0.03%]
基于UPLC-HRMS和实验验证飞泥宁方及其有效成分Apigenin抑制EGFR-TKI耐药非小细胞肺癌的作用机制研究
Yang Han,Lijing Jiao,Hailun Zhou et al.
Yang Han et al.
Ethnopharmacological relevance: Drug resistance in lung cancer poses a significant challenge in clinical treatment. Feiyanning formula (FYN) is a traditional Chinese medicine formula developed through years of clinical pr...
Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation [0.03%]
角膜扩张症中线粒体功能障碍的解析：基于机器学习的批量和单细胞转录组分析以及ACS L4的实验验证见解
Yuchen Cai,Tianyi Zhou,Xueyao Cai et al.
Yuchen Cai et al.
Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of corneal transplantation globally. Despite evidence of mitochondrial abnormalities in KC, the underlying mechanisms remain unclear. Our aim was to investigate t...
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation [0.03%]
探究线粒体代谢和免疫浸润在心肌梗死中的作用：生物信息学和实验验证的新见解
Jingyi Hou,Lihan Wang,Naiqiang Zhu et al.
Jingyi Hou et al.
Background: Mitochondrial metabolism and immune inflammation play pivotal roles in the MI pathogenesis of myocardial infarction (MI); however, their interplay remains unclear. This study aimed to clarify the roles of mito...
Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification [0.03%]
基于生物信息学和实验验证鉴定出Grb2蛋白可能作为急性胰腺炎中巨噬细胞活化的介导者
Qinhao Shen,Shuai Wang,Keyan Wu et al.
Qinhao Shen et al.
Introduction: Macrophage activation is closely associated with Acute pancreatitis (AP). We screened and found that Growth factor receptor bound protein 2 (Grb2) is highly expressed in macrophages during AP. However, the r...
Unveiling the immunopharmacological mechanisms of Danggui Yinzi (DGYZ) in treating chronic urticaria: insights from network pharmacology and experimental validation [0.03%]
当归饮子治疗慢性荨麻疹的免疫药理机制研究：网络药理学与实验验证相结合的探索性研究
Xu-Rui Wang,An-Jing Chen,Chang-Cheng Hou et al.
Xu-Rui Wang et al.
Background: Chronic urticaria (CU), a prevalent and often debilitating allergic skin disorder, is primarily triggered by mast cell degranulation. Danggui Yinzi (DGYZ), a traditional Chinese medicine formula, has been empl...
Integrating network pharmacology, experimental validation and molecular dynamics simulation to investigate the underlying mechanism of apigenin against diabetic wound [0.03%]
整合网络药理学、实验验证和分子动力学模拟研究芹菜素抗糖尿病伤口的潜在机制
Pengpeng Pu,Fangjian Zheng,Huihui Wang et al.
Pengpeng Pu et al.
Diabetic wounds (DW) are one of the complications of diabetes. They are difficult to repair and current treatment options are limited. In this study, we employed a network pharmacology approach to investigate the therapeutic potential of Ap...
Network pharmacology approach and experimental verification of earthworm protein in the treatment of diabetes mellitus-induced erectile dysfunction [0.03%]
基于网络药理学的蚯蚓蛋白改善糖尿病所致勃起功能障碍的作用研究及实验验证
Liming Liu,Yuanfeng Zhang,Aiping Zhang et al.
Liming Liu et al.
Background: Diabetes mellitus-induced erectile dysfunction (DMED) is a common complication of diabetes mellitus. Earthworm protein (EWP) is an active protein extracted from the Chinese herbal medicine earthworm, which is ...
Jingfang Granules for Diabetic Wound Healing: Insights from Network Pharmacology and Experimental Validation [0.03%]
网络药理学和实验验证指导下的金方颗粒治疗糖尿病创面促愈合效应研究
Rongrong Wang,Qian Wang,Mingfei Liu et al.
Rongrong Wang et al.
Background: Diabetic wounds are one of the most common complications of diabetes mellitus. Jingfang Granules (JFG), a combination of 11 herbs, has been clinically used for treating colds and the flu and for preventing var...
Exploring the anti-inflammatory effects of total flavonoids from L. gracile on LPS-induced inflammation: An integrated approach combining network pharmacology, molecular docking, and experimental validation [0.03%]
基于网络药理学、分子对接及实验验证的唇形科细裂筋骨草总黄酮抗炎效应研究
Xiaodie Li,Zhengqin Luo,Tingjun Hu et al.
Xiaodie Li et al.
Background: Lophatherum gracile Brongn., also known as Dan-Zhu-Ye, is traditionally used to clear heat and purge fire, relieve irritability and thirst, diuresis and catharsis. Our preliminary research revealed that total ...
Explore dual anti-inflammatory and cell protective mechanisms the mechanism of Jianwei Yuyang tablet in the treatment of alcohol-induced gastric ulcers via bioinformatics and experimental validation [0.03%]
基于生物信息学和实验验证的健胃愈疡片治疗酒精性胃溃疡双重抗炎与细胞保护机制探讨
Bilal Ahmed,Chenchen Jiang,Kexuan Huang et al.
Bilal Ahmed et al.
Background: Jianwei Yuyang Tablet (JWYY), a Chinese herbal formulation, has been approved for the treatment of various gastric diseases in clinic and has demonstrated significant therapeutic effects in patients with multi...
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