Stereoselective Synthesis of Secondary and Tertiary Boronic Esters via Matteson Homologation [0.03%]
立体选择性合成二级和三级硼酸酯的研究——迈特逊同系物化的应用
Markus Tost,Uli Kazmaier
Markus Tost
Matteson homologations of chiral boronic esters with lithium dichlorocarbenoids and various nucleophiles proved to be a useful method for the synthesis of functionalized polyketides in a highly stereoselective fashion. Via repeated homologa...
Substrate Plasticity Enables Group-Selective Transmetalation: Catalytic Stereospecific Cross-Couplings of Tertiary Boronic Esters [0.03%]
底物的塑形性实现组特异性转金属化：叔硼酸酯的催化立体选择性交叉偶联反应
Hao Liang,James P Morken
Hao Liang
Activation of enantiomerically enriched tertiary alkylboronic esters with adamantyllithium generated in situ enables stereoretentive boron-to-copper transmetalation. The resulting alkylcopper species can undergo cross-coupling reactions wit...
Enantioselective Construction of Carbocyclic and Heterocyclic Tertiary Boronic Esters by Conjunctive Cross-Coupling Reaction [0.03%]
串联交叉偶联反应构建光学活性碳环和杂环 tertiary 烷基硼酸酯
Xuntong Zhang,Chenpeng Gao,James P Morken
Xuntong Zhang
Synthesis of stereodefined carbocyclic and heterocyclic tertiary boronic esters is accomplished by performing a conjunctive cross-coupling reaction on preformed cyclic boron ate complexes. Boronates bearing spirocyclic and aryl bicyclic ske...
Computational assessments of diastereoselective [4+2] cycloaddition and 1,3-borotopic shift of a dearomatized tertiary boronic ester intermediate: reactivities explained through transition-state distortion energies [0.03%]
三级硼酸酯中间体的对映面选择性[4+2]环加成和1,3-硼迁移的计算评估：通过过渡态变形能量解释反应活性
Aqeel A Hussein,Faisal A Almalki,Alaa M Alqahtani et al.
Aqeel A Hussein et al.
Interception of a dearomatized tertiary boronic ester, formed through a kinetically and thermodynamically favorable 1,2-metalate rearrangement/anti-SN2' elimination of an activated ortho-lithiated benzyl amine, in a [4+2] cycloaddition or 1...
Enantioselective synthesis of tertiary boronic esters through catalytic asymmetric reversed hydroboration [0.03%]
催化不对称逆向硼化合成叔硼酸酯类化合物
Tao-Tao Gao,Hou-Xiang Lu,Peng-Chao Gao et al.
Tao-Tao Gao et al.
Chiral tertiary boronic esters are important precursors to bioactive compounds and versatile synthetic intermediates to molecules containing quaternary stereocenters. The development of conjugate boryl addition to α,β-unsaturated amide ha...
Highly Enantiospecific Borylation for Chiral α-Amino Tertiary Boronic Esters [0.03%]
高对映选择性硼化制备α-氨基三级硼酸酯类手性化合物
Qingqing Qi,Xuena Yang,Xiaoping Fu et al.
Qingqing Qi et al.
Herein we report a highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure (>99 % ee) α-amino tertiary boronic esters. The configurationally stable α-N-Boc substituted tertiary organolithium specie...
Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross-Coupling [0.03%]
串联交叉偶联法构建 tertiary 烷基硼酸酯类映异构体
Jesse A Myhill,Liang Zhang,Gabriel J Lovinger et al.
Jesse A Myhill et al.
Catalytic enantioselective conjunctive cross-coupling has been developed to construct tertiary alkylboronic esters. These reactions occur with good yield and enantioselectivity for a range of substrates. Mechanistic experiments reveal aspec...
Enantiospecific sp2 -sp3 Coupling of ortho- and para-Phenols with Secondary and Tertiary Boronic Esters [0.03%]
苯酚与二级和三级硼酸酯的面对映选择性sp2-sp3偶联反应
Claire M Wilson,Venkataraman Ganesh,Adam Noble et al.
Claire M Wilson et al.
The coupling of ortho- and para-phenols with secondary and tertiary boronic esters has been explored. In the case of para-substituted phenols, after reaction of a dilithio phenolate species with a boronic ester, treatment with Ph3 BiF2 or M...
Beatrice S L Collins,Claire M Wilson,Eddie L Myers et al.
Beatrice S L Collins et al.
Non-racemic chiral boronic esters are recognised as immensely valuable building blocks in modern organic synthesis. Their stereospecific transformation into a variety of functional groups-from amines and halides to arenes and alkynes-along ...
Synthesis of Chiral Tertiary Boronic Esters: Phosphonate-Directed Catalytic Asymmetric Hydroboration of Trisubstituted Alkenes [0.03%]
手性三级硼酸酯的合成：磷酸盐导向催化的三取代烯烃不对称氢硼化反应
Suman Chakrabarty,James M Takacs
Suman Chakrabarty
Highly enantioselective rhodium-catalyzed hydroboration of allylic phosphonates by pinacolborane affords chiral tertiary boronic esters. The β-borylated phosphonates are readily converted to chiral β- and γ-hydroxyphosphonates and aminop...
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