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Predrag Djuric,Zorica Mladenovic,Zoran Jovic et al. Predrag Djuric et al.
Background and Objectives: Factor VIII (FVIII) and the von Willebrand factor (vWF) are key components of hemostatic balance. Disruption of the vWF-ADAMTS13 axis, characterized by elevated vWF and reduced ADAMTS13 activity has been implicate...
Joshua Singavarapu,Galina Borodulina Joshua Singavarapu
Von Willebrand disease (vWD) is a common inherited bleeding disorder caused by a deficiency of von Willebrand factor (vWF), a glycoprotein involved in hemostasis. The two major roles of vWF are platelet adhesion and the stabilization of fac...
Yash Nagpal,Nisha Chachad,Paola Andrea Benito et al. Yash Nagpal et al.
Background and Clinical Significance: Left ventricular hypoplasia is often repaired surgically in sequence to a Fontan circulation, which is a physiologic state that presents unique challenges during pregnancy. Although women with Fontan ph...
Yang Lei,Weiheng Shi,Yanxi Guo et al. Yang Lei et al.
Keywords: Bacterial infection; Complement receptor 3 (CR3); Immunity; Oreochromis niloticus; von willebrand factor type A (vWFA) domain. Copyright © 2025 Elsevier Ltd. All rights reserved.
Pan Fu,Meiling Hu Pan Fu
Background: Previous studies have suggested that von Willebrand Factor (VWF) may be implicated in the pathogenesis of Alzheimer's disease (AD). However, the association between plasma VWF levels and cognitive decline and ...
Ziqi Zhang,Qian Liang,Xiaoqian Xu et al. Ziqi Zhang et al.
Gene therapy remains the only cure for von Willebrand disease (VWD), but is limited by the large von Willebrand factor (VWF) gene size. Variants affecting the VWF propeptide (VWFpp) impair multimerization, causing type 2A/IIC VWD. VWFpp ser...
Anna Olsson,Petra Elfvinge,Eva Zetterberg et al. Anna Olsson et al.
Introduction: Heavy menstrual bleeding (HMB) is a common and burdensome symptom in women with von Willebrand disease (VWD). Although VWD and HMB have been studied, the prevalence and impact of HMB across different age gro...
Thomas David Daniel Kazmirchuk,Jiashu Wang,Loredana Bury et al. Thomas David Daniel Kazmirchuk et al.
Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder caused by gain-of-function mutations in platelet glycoprotein Ib alpha (GPIbα). These mutations lead to a hyperactive protein-protein interaction (PPI) with von Will...
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