The influence of femtosecond laser intrastromal lenticules on the characteristics and maturity in tissue-engineered stem cell-derived retinal pigment epithelium sheets [0.03%]
飞秒激光制备的角膜基质透镜对组织工程诱导多能干细胞源性视网膜色素上皮片特性及成熟度的影响
Gu Jianing,Su Zhanyu,Wang Yini et al.
Gu Jianing et al.
Methods: iRPE cells were obtained by differentiating induced pluripotent stem cells (iPSC). These cells were then seeded on decellularized FLI-lenticules (dfLEN).
Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs [0.03%]
可编程的chrono遗传基因回路，用于生物药物的自我调节昼夜递送
Amanda Cimino,Fiona Pat,Omolabake Oyebamiji et al.
Amanda Cimino et al.
We compared expression of IL-1Ra from circuits that contained different circadian promoter elements (E'-boxes, D-boxes, or RREs) and their ability to respond to inflammatory challenges in murine pre-differentiated induced pluripotent stem cells (PDiPSC) or engineered cartilage pellets.
BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning [0.03%]
BMP、MEK和WNT抑制结合NGN2表达可促进hiPSC源性神经元的快速产生并有利于其区室化分型
Carina Habich,Alexandra Kowalski,Astrid Wachter et al.
Carina Habich et al.
Human induced pluripotent stem cells (hiPSCs) are a promising tool for studying neurological diseases and developing therapies for neurodegenerative diseases.
Application of human iPSC-derived white, beige, and brown adipocytes for metabolic disease modeling and transplantation therapy [0.03%]
人多能干细胞分化而来的白色、米色和褐色脂肪细胞在代谢性疾病建模及细胞治疗中的应用
Yamato Keidai,Junji Fujikura,Daisuke Yabe
Yamato Keidai
Human induced pluripotent stem cells (hiPSCs) offer a powerful platform for generating white, beige, and brown adipocytes, supporting both disease modeling and therapeutic research.
Exploiting induced pluripotent stem cell-derived retinal pigment epithelium to unravel host-pathogen interaction in ocular tuberculosis: a reverse translational in vitro model [0.03%]
利用诱导多能干细胞来源的视网膜色素上皮细胞揭示眼部结核病宿主-病原体相互作用：一种反向翻译体外模型
Ikhwanuliman Putera,Sanne van de Meerendonk,Nicole M A Nagtzaam et al.
Ikhwanuliman Putera et al.
To better understand the immunopathobiology of OTB, particularly an individual's susceptibility to Mtb-infection and the specific host response, cell culture systems utilizing induced pluripotent stem cells (iPSC)-derived RPE cells offer a promising in vitro model to better mimic the disease.
Simultaneous optical recording of action potentials and calcium transients in cardiac single cells differentiated from type 1 CPVT-iPS cells [0.03%]
来自第1型CPVT-iPS细胞分化的心脏单个细胞的动作电位和钙瞬变的同时光学记录
Tadashi Takaki,Norihisa Tamura,Kenichi Imahashi et al.
Tadashi Takaki et al.
Numerous reports investigating channelopathies, including Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), have successfully reproduced using cardiomyocytes (CMs) differentiated from human induced pluripotent stem cells (hiPSCs).
Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord [0.03%]
非病毒法诱导由犬脐带组织干细胞产生ipse细胞
Atsushi Yamazaki,Seiji Shiozawa,Yuko Koushige et al.
Atsushi Yamazaki et al.
In our previous study, canine induced pluripotent stem cells (iPSCs) were successfully generated from skin-derived fibroblasts, without the use of viral vectors.
Drug treatment alters performance in a neural microphysiological system of information processing [0.03%]
药物治疗改变信息处理的神经微型生理系统性能
Bradley Watmuff,Forough Habibollahi,Candice Desouza et al.
Bradley Watmuff et al.
Hyperactive glutamatergic dysregulation is linked to neurological disorders including epilepsy, and inducible overexpression of neurogenin 2 (NGN2) in human induced pluripotent stem cells (hiPSCs) generates glutamatergic cultures with dysregulated hyperactivity.
STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7-RALB axis [0.03%]
STAT1介导的LIN28A表观遗传调控通过let-7-RALB轴促进诱导多能干细胞来源血小板生成
Kazuya Hashimoto,Si Jing Chen,Kosuke Fujio et al.
Kazuya Hashimoto et al.
Ex vivo platelet production from induced pluripotent stem cells (iPSCs) represents a potential solution to address the limitations of donor-dependent platelet transfusion therapy.
Embryoid bodies as a model system for exploring early human embryonic development [0.03%]
以类胚胎体作为探索早期人类胚胎发育的模型系统
Daria I Zhigalina,Evgeny V Denisov,Igor N Lebedev et al.
Daria I Zhigalina et al.
The review also provides a comparative analysis of the advantages and limitations of models based on induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), with particular attention given to summarizing the results of limited studies on RNA sequencing in individual cells from human and
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