Metabolic brain disease. 2025 Jun 16;40(6):225. doi: 10.1007/s11011-025-01646-2 Q23.52025
Human placental extract rescues hippocampal damage associated with cognitive impairment in diabetic male rats through antioxidative, anti-inflammatory, and neuromodulatory activities
人胎盘提取物通过抗氧化、抗炎和神经调节作用拯救2型糖尿病雄性大鼠相关的海马损伤和认知障碍 翻译改进
Shreen Matar 1, Rehab A Gomaa 1, Abeer El Wakil 2, Amina Essawy 1
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DOI: 10.1007/s11011-025-01646-2 PMID: 40522516
摘要 中英对照阅读
记忆和认知障碍已成为与糖尿病相关的重要共病，但有效的治疗方法仍然难以找到。多项研究表明，人胎盘提取物（HPE）富含具有抗炎、抗氧化、抗凋亡和免疫调节作用的生物活性分子。然而，HPE对记忆和认知衰退的影响尚不明确。本研究旨在调查HPE对链脲佐菌素（STZ）诱导的大鼠记忆和认知功能障碍的治疗效果，并探讨其潜在机制。为了诱导2型糖尿病（T2DM），先给大鼠喂食高脂饮食两周，然后单次腹腔注射STZ（40 mg/kg体重），随后用HPE（20 mg/kg体重/天）治疗14天。行为测试结果显示，在接受STZ处理的大鼠中，HPE显著增强了学习、记忆和认知功能。具体而言，HPE在新物体识别测试中的辨别指数从STZ大鼠的负值增加到治疗大鼠的正值，并改善了T迷宫中的自发交替行为，从41.25 ± 8.25%提高至74.50 ± 8.50%。此外，HPE还显著提高了血清中胰岛素、血糖水平、胰岛素抵抗的稳态模型评估（HOMA-IR）以及脂质谱与未治疗糖尿病大鼠相比，并调节了海马组织中的氧化应激标志物、抗氧化剂、促炎细胞因子和神经化学物质水平，突出了其抗氧化和抗炎特性。值得注意的是，HPE治疗改善了海马的神经形态学并减少了DNA损伤。带有尾巴的细胞百分比从糖尿病大鼠的25.67 ± 0.33下降到接受HPE治疗后的13.67 ± 0.88。总之，HPE具有神经保护作用，并可能作为针对T2DM相关神经退行性症状的有前景的治疗方法。
关键词：海马；天然治疗产品；神经炎症；神经递质；氧化应激；2型糖尿病
© 2025. 作者保留所有权利。
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期刊名：Metabolic brain disease
缩写：METAB BRAIN DIS
ISSN：0885-7490
e-ISSN：1573-7365
IF/分区：3.5/Q2
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Human placental extract rescues hippocampal damage associated with cognitive impairment in diabetic male rats through antioxidative, anti-inflammatory, and neuromodulatory activities