Journal of structural biology: X. 2025 May 23:11:100127. doi: 10.1016/j.yjsbx.2025.100127 Q15.12025

Crystal structure of the CCA-adding enzyme from Arabidopsis thaliana

拟南芥CCA加酶的晶体结构翻译改进

Xiao Wang¹, Yuan-Yuan Li¹, Zi-Yan Dou¹, Jia Wang¹, Lin Liu¹

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¹ School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.

DOI: 10.1016/j.yjsbx.2025.100127 PMID: 40519583

The 3'-terminal CCA-end of tRNA is essential for the attachment of amino acids and correct positioning of the aminoacyl-tRNA in the ribosome. In higher plants, the CCA sequence is synthesized, maintained, and repaired by class-II CCA-adding enzymes encoded by a single nuclear gene but multi-targeted to the nucleus, cytoplasm, plastids, and mitochondria. The structure of plant class-II CCA-adding enzyme remains unsolved. Here we describe the crystal struct... ...点击完成人机验证后继续浏览

tRNA的3'-末端CCA尾部对于氨基酸的连接以及氨基酰-tRNA在核糖体中的正确定位至关重要。在高等植物中，CCA序列是由一个单一的核基因编码的II类CCA添加酶合成、维持和修复的，并且该酶被多靶向到细胞核、细胞质、叶绿体和线粒体。植物II类CCA添加酶的结构尚未解决。在这里，我们描述了拟南芥（Arabidopsis thaliana）II类CCA添加酶（At CCA）的晶体结构。At CCA的整体结构与其他II类CCA添加酶相似，但在主体域中存在显著差异。在体域和尾域之间对At CCA和其他II类CCA添加酶进行结构比较揭示了At CCA的三个特定区域。基于建模的At CCA-tRNA复合物表明，At CCA可能具有不同的tRNA结合模式。位于At CCA主体域中的这三个特定区域还提供了多靶向分类候选区域。

关键词： 拟南芥；CCA添加酶；晶体结构；蛋白质分类；tRNA加工。

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Crystal structure of the CCA-adding enzyme from Arabidopsis thaliana

拟南芥CCA加酶的晶体结构翻译改进

CCA-adding enzymes and poly(A) polymerases are all members of the same nucleotidyltransferase superfamily: characterization of the CCA-adding enzyme from the archaeal hyperthermophile Sulfolobus shibatae

硫化叶菌的CCA添加酶：CCA添加酶和多聚A聚合酶都是核苷酸转移酶超家族的成员：硫化叶菌Shibata株CCA添加酶的特性研究

Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP

嗜热脂肪芽孢杆菌CCA加尾酶及其与ATP或CTP复合物的晶体结构

Hfq stimulates the activity of the CCA-adding enzyme

Hfq促进CCA添加酶的活性

Crystal structure of oxidized cytochrome c(6A) from Arabidopsis thaliana

来自阿拉伯芥的细胞色素c(6A)的氧化结构

Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1

拟南芥维生素C缺陷型1蛋白VTC1的晶体结构

Crystal Structure of the Chloroplastic Glutamine Phosphoribosylpyrophosphate Amidotransferase GPRAT2 From Arabidopsis thaliana

拟南芥叶绿体谷氨酰胺-磷核糖焦磷酸氨转移酶GPRAT2的晶体结构

Crystal structure and functional characterization of a glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thaliana

来自拟南芥的葡萄糖胺-6-磷酸-N-乙酰基转移酶的晶体结构和功能表征

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution

拟南芥NADPH依赖型硫氧还蛋白还原酶的晶体结构（2.5埃分辨率）

Crystal structure of the CCA-adding enzyme from Arabidopsis thaliana

拟南芥CCA加酶的晶体结构 翻译改进

CCA-adding enzymes and poly(A) polymerases are all members of the same nucleotidyltransferase superfamily: characterization of the CCA-adding enzyme from the archaeal hyperthermophile Sulfolobus shibatae

硫化叶菌的CCA添加酶：CCA添加酶和多聚A聚合酶都是核苷酸转移酶超家族的成员：硫化叶菌Shibata株CCA添加酶的特性研究

Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP

嗜热脂肪芽孢杆菌CCA加尾酶及其与ATP或CTP复合物的晶体结构

Hfq stimulates the activity of the CCA-adding enzyme

Hfq促进CCA添加酶的活性

Crystal structure of oxidized cytochrome c(6A) from Arabidopsis thaliana

来自阿拉伯芥的细胞色素c(6A)的氧化结构

Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1

拟南芥维生素C缺陷型1蛋白VTC1的晶体结构

Crystal Structure of the Chloroplastic Glutamine Phosphoribosylpyrophosphate Amidotransferase GPRAT2 From Arabidopsis thaliana

拟南芥叶绿体谷氨酰胺-磷核糖焦磷酸氨转移酶GPRAT2的晶体结构

Crystal structure and functional characterization of a glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thaliana

来自拟南芥的葡萄糖胺-6-磷酸-N-乙酰基转移酶的晶体结构和功能表征

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution

拟南芥NADPH依赖型硫氧还蛋白还原酶的晶体结构（2.5埃分辨率）

拟南芥CCA加酶的晶体结构翻译改进