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NPJ Parkinson's disease. 2025 Jun 15;11(1):170. doi: 10.1038/s41531-025-01030-y Q18.22025

Cutaneous nerve fiber pathology and function in Parkinson's disease and atypical parkinsonism - a cohort study

帕金森病和非典型帕金森综合征患者的皮肤神经纤维病理和功能损伤：队列研究 翻译改进

Mattias Andréasson  1  2  3, Wojciech Paslawski  4, Astrid Juhl Terkelsen  5, Kristin Samuelsson  6  4, Henrik Zetterberg  7  8  9  10  11  12, Kaj Blennow  7  8  13  14, Páll Karlsson  5  15, Per Svenningsson  16  6  4

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作者单位

  • 1 Center for Neurology, Academic Specialist Center, Stockholm, Sweden. mattias.andreasson@ki.se.
  • 2 Department of Neurology, Karolinska University Hospital, Stockholm, Sweden. mattias.andreasson@ki.se.
  • 3 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. mattias.andreasson@ki.se.
  • 4 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • 5 Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
  • 6 Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
  • 7 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • 8 Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  • 9 Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  • 10 UK Dementia Research Institute at UCL, London, UK.
  • 11 Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
  • 12 Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
  • 13 Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
  • 14 Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China.
  • 15 Danish Pain Research Center, Health, Aarhus University, Aarhus, Denmark.
  • 16 Center for Neurology, Academic Specialist Center, Stockholm, Sweden.

    • DOI: 10.1038/s41531-025-01030-y PMID: 40517154

    摘要 中英对照阅读

    There is scientific evidence for ongoing neurodegeneration and alpha-synuclein pathology involving the peripheral nervous system in Parkinson's disease (PD) and multiple system atrophy (MSA). We explored putative disease-mirroring properties of cutaneous nerve fibers in patients with PD (n = 20), MSA (n = 12), four-repeat tauopathies (n = 11), and controls (n = 20). Assessments included clinical rating scales, blood sampling, sudomotor testing, skin punch... ...点击完成人机验证后继续浏览

    帕金森病（PD）和多系统萎缩症（MSA）中，有科学证据表明神经退行性病变和α-突触核蛋白病理涉及周围神经系统。我们研究了皮肤神经纤维在PD患者（n = 20），MSA患者（n = 12），四重复tau病患者（n = 11）以及对照组（n = 20）中的潜在疾病相似特性。评估包括临床评分量表，血液采样，自主神经系统测试，来自颈部和腿部的皮肤活检样本，并进行为期一年的随访。进行了皮肤α-突触核蛋白种子扩增试验（SAA）和表皮内神经纤维密度（IENFD）测定。在MSA患者中观察到电化学皮肤导电性降低，与临床评分有关。颈部皮肤SAA结果（PD vs 对照组）实现了100%的敏感性和70%的特异性用于检测PD。我们没有发现基线IENFD或一年变化在患者和对照组之间存在差异。基线IENFD、血浆神经丝轻链以及SAA动力学与MSA患者的临床疾病进展相关。皮肤可能在MSA中具有潜在的预后特性。

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    期刊名：Npj parkinsons disease

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    ISSN：N/A

    e-ISSN：2373-8057

    IF/分区：8.2/Q1

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