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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Jun 13:189:118242. doi: 10.1016/j.biopha.2025.118242 Q17.52025

Host-defence caerin 1.1 and 1.9 peptides suppress B16 melanoma growth by inducing apoptosis and disrupting lipid metabolism

宿主防御肽caerin 1.1和1.9通过诱导凋亡和扰乱脂质代谢来抑制B16黑素瘤生长 翻译改进

Jiawei Fu  1, Xinyi Song  1, Rongmi Mo  1, Bernardo Cavallazzi Sebold  2, Yuandong Luo  3, Junjie Li  3, Quanlan Fu  3, Hejie Li  4, Xiaosong Liu  5, Tianfang Wang  6, Guoying Ni  7

作者单位 +展开

作者单位

  • 1 The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, China; Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China.
  • 2 School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia.
  • 3 Zhong'ao Biomedical Technology (Guangdong) Co. Ltd., Zhongshan, Guangdong 528403, China.
  • 4 School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia.
  • 5 The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, China; Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China; Zhong'ao Biomedical Technology (Guangdong) Co. Ltd., Zhongshan, Guangdong 528403, China. Electronic address: xiaosongl@yahoo.com.
  • 6 School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia; Centre for Bioinnovation, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia. Electronic address: twang@usc.edu.au.
  • 7 The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, China; Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China; Zhong'ao Biomedical Technology (Guangdong) Co. Ltd., Zhongshan, Guangdong 528403, China. Electronic address: ngy2003@gmail.com.

    • DOI: 10.1016/j.biopha.2025.118242 PMID: 40516331

    摘要 中英对照阅读

    Caerin peptides, originally isolated from the skin secretions of Australian tree frogs of the genus Litoria, have shown potential as anti-cancer agents in previous studies. This study investigates the impact of caerin 1.1 and 1.9 (F1/F3) peptides on lipid and amino acid metabolism in B16 melanoma cells, assessing their effects on cell proliferation and the tumour microenvironment (TME). F1/F3 significantly inhibited the proliferation of B16 cells in vitro,... ...点击完成人机验证后继续浏览

    来自澳大利亚树蛙（Litorea属）皮肤分泌物中分离出的Caerin多肽在之前的研究中显示出作为抗癌剂的潜力。本研究调查了caerin 1.1和1.9（F1/F3）多肽对B16黑色素瘤细胞脂质和氨基酸代谢的影响，评估它们对细胞增殖及肿瘤微环境（TME）的作用。F1/F3显著抑制了体外培养的B16细胞的增殖，并且代谢组学分析发现，在小鼠模型中，包括溶血磷脂酰胆碱、磷脂酰胆碱、磷脂酰乙醇胺和多不饱和脂肪酸在内的脂质代谢物显著下调。通路富集分析进一步显示抑制了脂肪酸生物合成和不饱和脂肪酸的生成过程，这表明脂质代谢过程受到了损害。此外，在TME中观察到了促炎细胞因子表达水平升高及炎症巨噬细胞浸润现象，这些可能有助于增强抗肿瘤反应。F1/F3组中的支链氨基酸分解途径也不活跃，暗示乙酰辅酶A供应量的改变影响了脂质合成。值得注意的是，代谢物如3-羟基戊二酸和肉毒碱衍生物显著升高，这表明可能存在抗增殖和抗炎作用。这些发现表明Caerin多肽通过多种机制发挥抗癌效果，包括调节脂质代谢和免疫激活，在黑色素瘤及其他恶性肿瘤的组合疗法中具有潜在的应用前景。

    关键词：B16细胞；Caerin多肽；脂质代谢；黑色素瘤；代谢组学。

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    期刊名：Biomedicine & pharmacotherapy

    缩写：BIOMED PHARMACOTHER

    ISSN：0753-3322

    e-ISSN：1950-6007

    IF/分区：7.5/Q1

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    Host-defence caerin 1.1 and 1.9 peptides suppress B16 melanoma growth by inducing apoptosis and disrupting lipid metabolism