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Journal of Alzheimer's disease : JAD. 2025 Jun 12:13872877251337773. doi: 10.1177/13872877251337773 Q23.12025

Circulating short chain fatty acids in Alzheimer's disease: A cross-sectional observational study

阿尔茨海默病中循环短链脂肪酸的水平：横断面观察性研究 翻译改进

Moira Marizzoni  1, Luigi Coppola  2, Cristina Festari  3, Delia Luongo  4, Dominic Salamone  5, Daniele Naviglio  6, Andrea Soricelli  2, Peppino Mirabelli  7, Marco Salvatore  2, Annamaria Cattaneo  1  8, Giovanni B Frisoni  9

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作者单位

  • 1 Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
  • 2 IRCCS SYNLAB SDN, Naples, Italy.
  • 3 Laboratory of Neuroimaging and Alzheimer's Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
  • 4 Istituto di Biostrutture e Bioimmagini (I.B.B.) - CNR, Naples, Italy.
  • 5 Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
  • 6 Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • 7 AORN Santobono-Pausilipon, UOS Laboratori di Ricerca e Biobanca, Naples, Italy.
  • 8 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
  • 9 Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.

    • DOI: 10.1177/13872877251337773 PMID: 40501283

    摘要 中英对照阅读

    Short chain fatty acids (SCFAs), produced mainly by gut microbes, might play a role in the pathophysiology of Alzheimer's disease (AD). We examined the SCFAs profile in 28 individuals with cognitive impairment due to AD (CI-AD), 29 with cognitive impairment not due to AD (CI-NAD), and 10 cognitively unimpaired (CU). CI-AD showed higher levels of acetate and valerate and lower levels of butyrate than CU and CI-NAD (p < 0.018). Acetate separated CI-AD from ... ...点击完成人机验证后继续浏览

    短链脂肪酸（SCFAs）主要由肠道微生物产生，可能在阿尔茨海默病（AD）的发病机制中起作用。我们研究了28名因AD导致认知障碍（CI-AD）、29名非AD原因的认知障碍（CI-NAD）以及10名无认知障碍（CU）个体中的SCFAs谱型。与CU和CI-NAD相比，CI-AD显示出乙酸和缬氨酸水平较高而丁酸盐水平较低（p

    关键词：阿尔茨海默病；认知障碍；微生物群-肠-脑轴；短链脂肪酸。

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    Copyright © Journal of Alzheimer's disease : JAD. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Journal of alzheimers disease

    缩写：J ALZHEIMERS DIS

    ISSN：1387-2877

    e-ISSN：1875-8908

    IF/分区：3.1/Q2

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    Circulating short chain fatty acids in Alzheimer's disease: A cross-sectional observational study