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Science advances. 2025 Jun 13;11(24):eadq7332. doi: 10.1126/sciadv.adq7332 Q111.72024

Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli

人视网膜神经节细胞光电反应的建模研究进展 翻译改进

Denise Valente  1  2, Kari V Vienola  1  3, Robert J Zawadzki  1  4, Ravi S Jonnal  1

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作者单位

  • 1 Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, Sacramento, CA 95817, USA.
  • 2 Fisica de Materiais, Escola Politecnica de Pernambuco, Universidade de Pernambuco, 50720-001 Recife PE, Brazil.
  • 3 Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
  • 4 EyePod small animal ocular imaging laboratory, Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA.

    • DOI: 10.1126/sciadv.adq7332 PMID: 40498834

    摘要 中英对照阅读

    Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are compelling and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe an optoretinographic imaging platform: full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.

    Keywords：human photoreceptor; function; modeling; optoretinographic; response

    光视网膜成像是检测和测量活体人眼视网膜神经元功能反应的一种新兴方法。其潜在应用广泛而令人信服，涵盖了视网膜疾病的临床评估、基础科学问题的研究以及针对致盲性视网膜疾病实验疗法的快速评价等领域。在这些领域取得进展的关键在于开发出能够量化观察到的响应与可见刺激之间关系的稳健方法。在这项工作中，我们描述了一个光视网膜成像平台：全视野扫频源光学相干断层扫描结合自适应光学技术，并测量了两位健康志愿者对多种刺激模式下的锥体反应，并提出了一种简单模型来预测和量化这些刺激所引起的响应。

    关键词：人视网膜感光细胞; 功能; 建模; 光学视网膜图谱技术; 响应

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    期刊名：Science advances

    缩写：SCI ADV

    ISSN：2375-2548

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    IF/分区：11.7/Q1

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    Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli