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Translational psychiatry. 2025 Jun 6;15(1):194. doi: 10.1038/s41398-025-03403-6 Q16.22025

Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses

利用流形学习和网络分析揭示精神分裂症和I型躁郁症的差异性精神病理症状 翻译改进

Young Hoon Kim  1, Jinhyeok Jang  1, Nuree Kang  1, Jae Hoon Jeong  1, Jayoun Kim  2, Yong Min Ahn  1  3, Yong Sik Kim  4, Se Hyun Kim  5  6

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作者单位

  • 1 Department of Psychiatry, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
  • 2 Medical Research Collaborating Center, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
  • 3 Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
  • 4 Department of Psychiatry, Nowon Eulji Medical Center, Eulji University, 327 Gongneung-ro, Nowon-gu, Seoul, 01830, Republic of Korea. kys@snu.ac.kr.
  • 5 Department of Psychiatry, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. sh3491@snu.ac.kr.
  • 6 Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. sh3491@snu.ac.kr.
  • DOI: 10.1038/s41398-025-03403-6 PMID: 40481013

    摘要 中英对照阅读

    The field of psychiatry has encountered ongoing challenges in understanding the intricate nature of psychotic symptoms, particularly when they manifest in individuals diagnosed with bipolar disorder or schizophrenia. In this study, we employed manifold and network analyses to investigate whether the pattern of symptom occurrence differs between schizophrenia and bipolar I disorder. We analyzed data collected from 555 individuals, 282 of whom were diagnosed... ...点击完成人机验证后继续浏览

    精神医学领域一直在努力理解精神病性症状的复杂性质,特别是在被诊断为双相情感障碍或精神分裂症的个体中。在这项研究中,我们采用了多面体和网络分析来探讨精神分裂症与I型双相情感障碍的症状发生模式是否存在差异。我们分析了来自555名个体的数据,其中282人被诊断为精神分裂症相关疾病,273人被诊断为I型双相情感障碍。在精神分裂症的背景下,消极症状(特别是无动机)较为突出,多面体和网络分析将无动机确定为一个高中心化的症状,与氯氮平使用、恶化模式、缓解倾向及病情严重程度相关。相反,在I型双相情感障碍中,积极症状在网络分析中起着核心作用。令人意外的是,多面体分析揭示了两个不同的患者群组,表明在I型双相情感障碍中精神病性症状的轮廓存在变异性。总之,精神分裂症和I型双相情感障碍虽然共享精神病性症状,但其共现模式有所不同。精神分裂症表现出消极症状,而I型双相情感障碍则表现出更强的精神病性症状之间的相互连接性,这突显了理解精神疾病中精神病性症状复杂性的必要性。

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    期刊名:Translational psychiatry

    缩写:TRANSL PSYCHIAT

    ISSN:2158-3188

    e-ISSN:2158-3188

    IF/分区:6.2/Q1

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    Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses