Allergic rhinitis (AR) has become a global health concern due to its increasing prevalence, significantly impacting the quality of life. Traditional treatment options often provide only temporary symptom relief and may cause adverse effects, leading to the exploration of alternative therapies. This study evaluates the effectiveness and safety of standardized Saururus chinensis extract (LHF618) for alleviating symptoms of AR. Over a 4-week period, patients receiving LHF618 showed significant reductions in total nasal symptom scores, particularly for symptoms such as nasal itching, sneezing, and congestion, compared with the control group. Additionally, LHF618 led to a marked improvement in rhinitis control assessment test scores and a significant reduction in specific immunoglobulin E levels related to dust mite allergens. Importantly, no significant adverse effects were observed, indicating that LHF618 is a well-tolerated and safe option. These findings suggest LHF618 could be a promising natural alternative for managing AR, especially in cases related to dust mite allergies.

Keywords: IgE; LHF618; RCAT; Saururus chinensis; TNSS; allergic rhinitis.

过敏性鼻炎（AR）已成为全球健康问题，由于其发病率不断上升，严重影响了生活质量。传统治疗方法往往只能提供暂时的症状缓解，并可能产生不良反应，因此探索替代疗法变得十分重要。本研究评估了标准化的山慈姑提取物（LHF618）在缓解过敏性鼻炎症状方面的有效性和安全性。经过4周的治疗，服用LHF618的患者表现出总鼻部症状评分显著降低，尤其是鼻痒、打喷嚏和鼻塞等症状较对照组有明显改善。此外，LHF618还导致了鼻炎控制评估测试（RCAT）分数的明显提高，并且与尘螨过敏原相关的特异性免疫球蛋白E（IgE）水平也有显著下降。重要的是，在治疗过程中没有观察到明显的不良反应，表明LHF618是一种耐受性和安全性良好的选择。这些发现提示LHF618可能是管理过敏性鼻炎的一种有前景的天然替代品，特别是对于尘螨过敏相关的病例。

关键词：IgE；LHF618；RCAT；山慈姑；TNSS；过敏性鼻炎。