As prevalence of obesity increases dramatically, obesity-associated cardiac dysfunction constitutes a huge challenge to human health. This study aims to find more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction. By retrospectively analyzing the clinical characteristics of 5,648 disease patients, we find that both plasma level of high-density lipoprotein (HDL-C) and blood monocyte count have significant associations with left ventricular ejection fraction (LVEF) impairment. Univariate and multivariate regression analyses reveal that monocyte to HDL-C ratio (MHR) is stronger in predicting risk of LVEF decline than both HDL-C and monocyte. Mediation analysis further indicates a mediative effect of high MHR on the obesity-associated cardiac systolic function decline. As such, our results demonstrate a superior role of MHR in predicting risk of obesity-associated decline in cardiac systolic function among the routine metabolic/inflammatory markers.

Keywords: cardiac dysfunction; left ventricular ejection fraction; monocyte to HDL-C ratio; obesity.

随着肥胖症的发病率急剧上升，与肥胖相关的心脏功能障碍对人类健康构成了巨大挑战。本研究旨在寻找更多有用的脂质/炎症标志物来预测肥胖引起的心脏功能障碍风险。通过对5,648名疾病患者的临床特征进行回顾性分析，我们发现血浆高密度脂蛋白（HDL-C）水平和血液单核细胞计数与左心室射血分数（LVEF）受损有显著关联。单变量和多变量回归分析显示，单核细胞与HDL-C比值（MHR）在预测LVEF下降风险方面比单独的HDL-C或单核细胞更强。中介分析进一步表明高MHR对肥胖相关心脏收缩功能下降具有中介作用。因此，我们的结果表明，在常规代谢/炎症标志物中，MHR在预测肥胖引起的心脏收缩功能下降的风险方面发挥着更优越的作用。

关键词：心脏功能障碍；左心室射血分数；单核细胞与HDL-C比值；肥胖。