Recent years have seen a search for more effective forms of asthma therapy, with one possible option being vitamin D supplementation. The main objective of this study was to present the current state of knowledge on the effect of vitamin D supplementation on the course of asthma in children and adults; it also reviews the existing literature on prenatal vitamin D supplementation and asthma status. The search comprised articles, mostly randomized controlled trials (RCTs), included in the PubMed database and published after 2018. Most RCTs conducted on children indicate that vitamin supplementation did not affect the course of the disease, its control, or exacerbations; however, several trials in adults confirm it to have beneficial effects, with an important role being played by vitamin D deficiency. Unfortunately, the studies demonstrated considerable heterogeneity concerning the age and number of participants, dose, duration, and use of guidelines for pharmaceutical drugs, making it difficult to draw clear conclusions. Further, properly designed, large-scale studies with long-term follow-ups are needed.

Keywords: 25-hydroxyvitamin D; Asthma; Observational studies; Randomized controlled trials; Vitamin D; Vitamin D supplementation.

© 2025. The Author(s).

近年来，人们一直在寻找更有效的哮喘治疗方法，其中一种可能的选项是维生素D补充。本研究的主要目的是介绍维生素D补充对儿童和成人哮喘病程的影响的现有知识状态；同时回顾了有关孕期维生素D补充与哮喘状况的相关文献。搜索涵盖了主要为随机对照试验（RCTs）的文章，并且这些文章收录在PubMed数据库中，且发表于2018年之后。大多数针对儿童进行的RCT研究表明，维生素补充并未影响疾病的进程、控制或加重；然而，在成年人中的几项试验证实了其具有有益的效果，特别是对于维生素D缺乏的情况尤为明显。不幸的是，研究在年龄和参与者数量、剂量、持续时间以及药物指南的应用方面存在较大的异质性，这使得难以得出明确的结论。因此，需要进行设计合理的大规模长期跟踪研究。

关键词：25-羟基维生素D；哮喘；观察性研究；随机对照试验；维生素D；维生素D补充。