Objective: To investigate the association between the New Early Warning Score (NEWS) and 28-day mortality in patients with severe fever with thrombocytopenia syndrome (SFTS).

Design: A cross-sectional derivation and validation study.

Methods: A total of 382 SFTS patients were included in retrospective and prospective studies. The primary outcome was short-term (28-day) mortality. Cox regression, receiver operating characteristic (ROC), and Kaplan-Meier analysis were utilised in the retrospective study to assess the association between NEWS and mortality. The prospective study assessed the applicability of the NEWS.

Reporting method: This study was reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.

Results: Among 219 SFTS patients in the retrospective study, 27 (12.3%) died within 28 days. NEWS was significantly higher in non-survivors than in survivors (4.00 [1.00, 5.00] vs. 1.00 [1.00, 2.00]). The ROC curve for MEWS predicting 28-day mortality showed an area under the curve (AUC) of 0.757 (95% confidence interval: 0.65-0.87), with a cut-off of 3.5 (sensitivity: 90.6%; specificity: 55.6%). SFTS patients were stratified into low (NEWS < 4), medium (NEWS 4-6), and high (NEWS > 6) risk groups. Kaplan-Meier analysis showed significantly lower survival rates in medium and high risk groups compared to the low risk group. The prospective study included 63 SFTS patients, of whom 11 (17.5%) died. 28-day mortality significantly increased across NEWS categories: [low risk (4/50, 8.0%), medium risk (4/8, 50.0%), high risk (3/5, 60.0%)].

Conclusions: NEWS was a quicker, simpler, and valuable parameter to identify SFTS patients at risk of 28-day mortality.

Relevance to clinical practice: An elevated NEWS at admission is associated with a higher risk of poor short-term prognosis in SFTS patients. Incorporating NEWS into emergency nursing practice may aid in the early identification of SFTS patients at risk of adverse prognosis.

Patient or public contribution: Emergency nurses performed the NEWS for the SFTS patients at admission.

Keywords: mortality; new early warning score; predictive performance; severe fever with thrombocytopenia syndrome.

© 2025 John Wiley & Sons Ltd.

目标： 研究新早期预警评分（NEWS）与发热伴血小板减少综合征（SFTS）患者28天死亡率之间的关联。

设计： 一项横断面的派生和验证研究。

方法： 回顾性和前瞻性研究共纳入382名SFTS患者。主要结局是短期（28天）死亡率。回顾性研究利用Cox回归、受试者工作特征曲线（ROC）和Kaplan-Meier分析评估NEWS与死亡率之间的关联。前瞻性研究评估了NEWS的适用性。

报告方法： 该研究遵循流行病学观察性研究加强报告规范（STROBE）指南进行报告。

结果： 回顾性研究中的219名SFTS患者中，有27人（12.3%）在28天内死亡。非幸存者组的NEWS评分显著高于幸存者组（4.00 [1.00, 5.00] vs. 1.00 [1.00, 2.00]）。MEWS预测28天死亡率的ROC曲线显示曲线下面积（AUC）为0.757（95%置信区间：0.65-0.87），临界值为3.5（敏感性：90.6%；特异性：55.6%）。SFTS患者被分为低风险（NEWS 6）组。Kaplan-Meier分析显示，与低风险组相比，中等风险组和高风险组的生存率显著较低。前瞻性研究纳入了63名SFTS患者，其中11人（17.5%）死亡。不同NEWS类别的28天死亡率显著增加：[低风险（4/50, 8.0%），中等风险（4/8, 50.0%），高风险（3/5, 60.0%）]。

结论： NEWS是快速、简单且有价值的参数，用于识别有28天死亡风险的SFTS患者。

临床实践相关性： 入院时升高的NEWS与SFTS患者的不良短期预后风险增加有关。将NEWS纳入急诊护理实践中可能有助于早期识别具有不利预后的SFTS患者。

病人或公众贡献： 急诊护士在患者入院时为SFTS患者进行了NEWS评分。

关键词： 死亡率；新早期预警评分；预测性能；发热伴血小板减少综合征。