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Randomized Controlled Trial Alzheimer's & dementia : the journal of the Alzheimer's Association. 2025 May;21(5):e70156. doi: 10.1002/alz.70156 Q111.12024

Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial

听觉干预的认知效益因认知衰退风险的不同而不同：来自ACHIEVE试验的二次分析结果 翻译改进

James Russell Pike  1, Alison R Huang  2  3, Nicholas S Reed  1, Michelle Arnold  4, Theresa Chisolm  4, David Couper  5, Jennifer A Deal  2  3  6, Nancy W Glynn  7, Adele M Goman  8, Kathleen M Hayden  9, Christine M Mitchell  2, James S Pankow  10, Victoria Sanchez  11, Kevin J Sullivan  12, Nasya S Tan  13, Josef Coresh  1, Frank R Lin  2  3  6  14; ACHIEVE Collaborative Research Group

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作者单位

  • 1 Optimal Aging Institute, New York University Grossman School of Medicine, New York, New York, USA.
  • 2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • 3 Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • 4 Department of Communication Sciences & Disorders, College of Behavioral & Community Sciences, University of South Florida, Tampa, Florida, USA.
  • 5 Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
  • 6 Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • 7 Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
  • 8 School of Health and Social Care, Edinburgh Napier University, Edinburgh, UK.
  • 9 Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • 10 Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
  • 11 Department of Otolaryngology-Head & Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
  • 12 The MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • 13 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • 14 Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA.

    • DOI: 10.1002/alz.70156 PMID: 40369891

    摘要 中英对照阅读

    Introduction: Results from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial suggest hearing intervention may not reduce 3-year cognitive decline in all older adults with hearing loss but may be beneficial in certain groups. This secondary analysis investigated if participants with multiple risk factors for cognitive decline received greater benefits.

    Methods: We used a sample of dementia-free participants (N = 2692) from the Atherosclerosis Risk in Communities (ARIC) cohort to develop a predictive model for cognitive decline. The model was applied to baseline measures of ACHIEVE participants (N = 977) to estimate predicted risk. We tested an interaction between predicted risk and randomization to hearing intervention or health education control.

    Results: Among ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% confidence interval [CI]: 33.7%-94.1%) slower than the control.

    Discussion: The effect of hearing intervention on reducing 3-year cognitive decline was greatest among individuals with multiple baseline risk factors associated with faster cognitive decline.

    Trial registration: ClinicalTrials.gov Identifier: NCT03243422 HIGHLIGHTS: The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial tested the effect of hearing intervention on cognitive decline. Participants were recruited from the Atherosclerosis Risk in Communities (ARIC) cohort or de novo from the local community. A 48% reduction in cognitive decline was observed in ARIC cohort participants. In this secondary analysis, there was an interaction between hearing intervention and predicted risk of cognitive decline. Among participants in the top quartile of predicted risk of cognitive decline, hearing intervention slowed cognitive decline by 62%.

    Keywords: aging; cognition; cognitive decline; dementia; hearing; hearing aids; hearing loss; memory; presbycusis; randomized control trial.

    Keywords：cognitive benefits; hearing intervention; cognitive decline

    简介： ACHIEVE试验的结果表明，听力干预可能不会减少所有患有听力损失的老年人三年的认知衰退，但对于某些群体可能会有好处。这项二次分析研究了具有多种认知衰退风险因素的参与者是否能获得更大的益处。

    方法： 我们使用来自动脉粥样硬化风险社区（ARIC）队列中无痴呆症参与者的样本（N=2692），开发了一个预测认知衰退的模型。该模型应用于ACHIEVE参与者基线测量值（N=977），以估计预测的风险。我们测试了预测风险与随机分配到听力干预或健康教育对照组之间的相互作用。

    结果： 在ACHIEVE参与者的预测风险最高四分位数中，听力干预组三年的认知衰退速度比对照组慢61.6%（95%置信区间[CI]：33.7%-94.1%）。

    讨论： 听力干预对减少三年认知衰退的效果在基线风险因素与更快的认知衰退相关的个体中最大。

    试验注册信息： ClinicalTrials.gov 标识符：NCT03243422 突出显示：ACHIEVE试验测试了听力干预对认知衰退的影响。参与者来自动脉粥样硬化风险社区（ARIC）队列或当地社区新招募的人员。在ARIC队列参与者中观察到认知衰退减少了48%。在这项二次分析中，听力干预与预测的认知衰退风险之间存在相互作用。对于处于预测认知衰退风险最高四分位数的参与者，听力干预使认知衰退减慢了62%。

    关键词： 老龄化；认知功能；认知衰退；痴呆症；听力；助听器；听力损失；记忆；老年性耳聋；随机对照试验

    关键词：认知益处; 听力干预; 认知衰退

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    Copyright © Alzheimer's & dementia : the journal of the Alzheimer's Association. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Alzheimers & dementia

    缩写：ALZHEIMERS DEMENT

    ISSN：1552-5260

    e-ISSN：1552-5279

    IF/分区：11.1/Q1

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