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Review Journal of clinical immunology. 2025 May 13;45(1):93. doi: 10.1007/s10875-025-01885-z Q15.72025

Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review

既往二十年干扰素γ自身抗体相关成人发病原发性免疫缺陷临床特征及诊断进展——一例报告与文献复习 翻译改进

Liyan Zhao  1, Jindi Ma  1, Ying Sun  1, Xiaopeng Yu  1, Yingfeng Lu  1, Haijiang Qian  2, Ren Yan  3, Yimin Zhang  4  5

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作者单位

  • 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • 2 Department of Infectious Diseases, Haining People's Hospital, Haining, China.
  • 3 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 1514090@zju.edu.cn.
  • 4 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 1307020@zju.edu.cn.
  • 5 Department of Infectious Diseases, Haining People's Hospital, Haining, China. 1307020@zju.edu.cn.

    • DOI: 10.1007/s10875-025-01885-z PMID: 40360799

    摘要 中英对照阅读

    Anti-interferon-gamma autoantibody (AIGA)-associated adult-onset immunodeficiency (AOID) is an emerging disease that can lead to serious opportunistic infections, which has a history of 20 years since it was first reported in 2004. It's a hard-detected AOID caused by AIGA. In recent years, there has been an increasing number of reports on the disease, but there is still a lack of consensus on the diagnosis and treatment. We here report a case of a 70-year... ...点击完成人机验证后继续浏览

    抗干扰素-γ自身抗体（AIGA）相关的成人期起病免疫缺陷（AOID）是一种可导致严重机会性感染的新兴疾病，自2004年首次报告以来已有20年的历史。这是一种由AIGA引起的难以检测到的AOID。近年来关于该疾病的报道越来越多，但在诊断和治疗方面仍缺乏共识。我们在此报道了一例70岁中国男性患者案例，其血清中存在AIGA并反复出现脓胸。尽管每次接受抗菌药物治疗后病情有所改善，但他的脓胸经常复发，需要反复住院。对与AIGA相关的AOID文献进行了回顾。我们在PubMed、Web of Science、Embase和中文文献数据库中搜索了关于AIGA的论文。符合标准且检测到AIGA的病例被纳入分析。共回顾性分析了502例患者，其中男性256例（51.0%），女性246例（49.0%）。大多数患者来自东南亚（98.2%）。淋巴结是最常见的受累器官（占83.7%），其次是肺部（占60.6%）。非结核分枝杆菌（NTM）是报告中主要的病原体，占77.49%。该疾病的临床表现多样且不具有特异性，常表现为多系统受累和反复感染。及时识别AIGA患者、适当诊断及个体化治疗至关重要；因此，我们根据研究结果提出了一项合理的诊断标准以及结构化的诊断与治疗流程，以向临床医生提供全面的实践信息。

    关键词： 马尼菲青霉菌；成人期起病免疫缺陷；抗干扰素-γ自身抗体；非结核分枝杆菌；脓胸。

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    期刊名：Journal of clinical immunology

    缩写：J CLIN IMMUNOL

    ISSN：0271-9142

    e-ISSN：1573-2592

    IF/分区：5.7/Q1

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    Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review