Polydimethylsiloxane (PDMS) chips are still the workhorses of academic microfluidics. Their production requires the fabrication of moulds, commonly produced using clean-room technologies. Light-based 3D printing and in particular, vat photopolymerization, material jetting and two-photon polymerization are rising techniques for the fabrication of moulds for PDMS replication, thanks to their accessibility, fast prototyping time, and improving resolution. Here, we are first reviewing the possibility opened by 3D printing for soft lithography, with a focus on mould designs. Then, inhibition of PDMS curing by photosensitive resins will be discussed as the main technical hurdle of 3D printed moulds. Fortunately, mould post-treatments are efficient solutions to eliminate this curing inhibition, which we gathered in a large database of post-treatment protocols from the literature.
Review Lab on a chip. 2025 Apr 7. doi: 10.1039/d4lc00836g Q16.12024
Light-based 3D printing and post-treatments of moulds for PDMS soft lithography
基于光的3D打印和用于PDMS软刻蚀模子的后处理技术 翻译改进
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DOI: 10.1039/d4lc00836g PMID: 40190179
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