Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2025 Apr 1:115417. doi: 10.1016/j.fct.2025.115417 Q23.92024
RIFM fragrance ingredient safety assessment, nonyl alcohol, CAS Registry Number 143-08-8
香味组分安全评估(RIFM)，2-羟基壬醛(又名非尼醇)，化学文摘号143-08-8 翻译改进
A M Api 1, A Bartlett 1, D Belsito 2, D Botelho 1, M Bruze 3, A Bryant-Friedrich 4, G A Burton Jr 5, M A Cancellieri 1, H Chon 1, M Cronin 6, S Crotty 1, M L Dagli 7, W Dekant 8, C Deodhar 1, K Farrell 1, A D Fryer 9, L Jones 1, K Joshi 1, A Lapczynski 1, D L Laskin 10, M Lavelle 1, I Lee 1, H Moustakas 1, J Muldoon 1, T M Penning 11, A H Piersma 12, G Ritacco 1, N Sadekar 1, I Schember 1, T W Schultz 11, F Siddiqi 1, I G Sipes 13, G Sullivan 14, Y Thakkar 1
作者单位 +展开
作者单位
1 Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ 07430, USA.2 Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.3 Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.4 Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI 48202, USA.5 Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI 58109, USA.6 Member Expert Panel for Fragrance Safety, Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Liverpool, United Kingdom.7 Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.8 Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.9 Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon 97239 USA.10 Member Expert Panel for Fragrance Safety, Rutgers University Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA.11 Member of Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104-3083, USA.12 Member Expert Panel for Fragrance Safety, Utrecht University, Institute for Risk Assessment Sciences (IRAS), Netherlands.13 Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.14 Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ 07430, USA. Electronic address: gsullivan@rifm.org.
DOI: 10.1016/j.fct.2025.115417 PMID: 40180305
摘要 Ai翻译
Nonyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog heptyl alcohol (CAS # 111-70-6) show that nonyl alcohol is not expected to be genotoxic and provide a calculated Margin of Exposure (MOE) >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across analog 1-decanol (CAS # 112-30-1) provided nonyl alcohol a No Expected Sensitization Induction Level (NESIL) of 10000 μg/cm2 for the skin sensitization endpoint. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; nonyl alcohol is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to nonyl alcohol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; nonyl alcohol was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
Copyright © 2025. Published by Elsevier Ltd.
Keywords：nonyl alcohol
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