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The Journal of nutrition. 2025 Mar 19:S0022-3166(25)00167-1. doi: 10.1016/j.tjnut.2025.03.015 Q23.72024

Plasma Proteins Associated with the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Incident Dementia

与地中海-停止高血压饮食方法以延缓神经退行性疾病(思维 diet)和新发痴呆有关的血浆蛋白 翻译改进

Jiaqi Yang  1, Lauren Bernard  2, Jingsha Chen  1, Valerie K Sullivan  1, Jennifer A Deal  3, Hyunju Kim  4, Bing Yu  5, Lyn M Steffen  6, Casey M Rebholz  7

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作者单位

  • 1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA.
  • 2 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA; School of Medicine, University of Maryland, Baltimore, Maryland, USA.
  • 3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • 4 Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
  • 5 Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
  • 6 Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
  • 7 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: crebhol1@jhu.edu.

    • DOI: 10.1016/j.tjnut.2025.03.015 PMID: 40118346

    摘要 Ai翻译

    Background: The Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet slows cognitive decline and protects brain health, but the mechanisms are poorly understood.

    Objectives: We aimed to determine the plasma proteins associated with the MIND diet score and their ability to predict incident dementia in the Atherosclerosis Risk in Communities study.

    Methods: We analyzed 10,230 Black and White participants at visit 3 (1993-1995) with food frequency questionnaire and proteomics data and randomly divided them into discovery (n = 6,850) and replication (n = 3,380) samples. We examined associations between the MIND diet score and 4,955 proteins using multivariable linear regression and elastic net regression. C-statistics were calculated to assess if proteins improved prediction of high MIND diet adherence beyond participant characteristics. Cox proportional hazards models were used to assess associations between significant diet-related proteins and incident dementia over two decades. C-statistics assessed the ability of significant proteins to improve dementia prediction beyond known risk factors.

    Results: Of 316 proteins associated with the MIND diet score in the discovery sample at a false discovery rate < 0.05, 62 were internally replicated. Of these, 21 proteins selected by the elastic net individually improved MIND diet score prediction. After a median follow-up of 21 years, there were 2,311 dementia cases. Five diet-related proteins, thrombospondin-2 (HR, 1.19; 95% CI, 1.11-1.29), protein ABHD14A (HR, 1.23; 95% CI, 1.11-1.37), structural maintenance of chromosomes protein 3 (HR, 1.19; 95% CI, 1.08-1.31), epidermal growth factor receptor (HR, 0.68; 95% CI, 0.53-0.86), and interleukin-12 subunit beta (HR, 1.14; 95% CI, 1.05-1.25) were significantly associated with incident dementia. All five proteins individually and together improved prediction of dementia risk.

    Conclusion: Using high-throughput proteomics, we identified candidate biomarkers of the MIND diet score and incident dementia, which are implicated in neural signaling, angiogenesis, and anti-inflammatory pathways.

    Keywords: ARIC; MIND diet; biomarkers; incident dementia; risk prediction; untargeted proteomics.

    Keywords：incident dementia; Plasma Proteins; MIND Diet

    关键词：新发痴呆症; 血浆蛋白质; 心灵饮食

    Copyright © The Journal of nutrition. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Journal of nutrition

    缩写：J NUTR

    ISSN：0022-3166

    e-ISSN：1541-6100

    IF/分区：3.7/Q2

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    Plasma Proteins Associated with the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Incident Dementia