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The Annals of pharmacotherapy. 2025 Mar 12:10600280251319519. doi: 10.1177/10600280251319519 Q32.32024

The Albumin-Bilirubin-Fibrosis-4 Score for Predicting Teicoplanin-Induced Abnormal Liver Enzyme Levels in Patients Undergoing Therapeutic Drug Monitoring: A Multicentral Retrospective Cohort Study

白蛋白-胆红素-肝纤维化4评分在治疗药物监测下预测茶剂平净诱导的异常肝脏酶水平:一项多中心回顾队列研究 翻译改进

Hayahide Ooi  1, Yuki Asai  2, Yoshihiro Kondo  3, Takumi Tashiro  4, Nobuyuki Zakoji  5, Maria Aoki  6, Yoshiki Koriyama  7, Takuya Iwamoto  2, Masaaki Takahashi  1

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作者单位

  • 1 Pharmacy, National Hospital Organization Mie Chuo Medical Center, Tsu, Japan.
  • 2 Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, Tsu, Japan.
  • 3 Pharmacy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • 4 Pharmacy, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
  • 5 Pharmacy, National Hospital Organization Shizuoka Medical Center, Shimizu, Japan.
  • 6 Pharmacy, National Center for Geriatrics and Gerontology, Obu, Japan.
  • 7 Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
  • DOI: 10.1177/10600280251319519 PMID: 40071844

    摘要 Ai翻译

    Background: Although therapeutic drug monitoring (TDM) maintains serum teicoplanin (TEIC) concentration between 15 and 30 μg/mL, TEIC-induced liver injury may still occur. The albumin-bilirubin (ALBI)-fibrosis-4 (FIB-4) score may be useful for predicting TEIC-induced liver injury in patients undergoing TDM.

    Objective: This pilot study aimed to investigate whether the ALBI-FIB4 score can predict TEIC-induced abnormal liver enzyme levels in patients undergoing TDM.

    Methods: The multicenter retrospective cohort study included 140 patients undergoing TDM of TEIC at steady state. The primary outcome was TEIC-induced abnormal liver enzyme levels. Cut-off values for the alanine aminotransferase (ALT), ALBI score, FIB-4 index, and ALBI-FIB4 score were detected using receiver-operating characteristic curves. The cumulative risk of TEIC-induced abnormal liver enzyme levels was evaluated using Kaplan-Meier curves analyzed log-rank test. Subgroup analysis was performed to examine cumulative risk in patients with serum TEIC concentration of <30 μg/mL.

    Results: The incidence of TEIC-induced abnormal liver enzyme levels was 14.3% (20/140). Cut-off values were 24 IU/L for ALT (sensitivity: 0.800; specificity: 0.692; area under the curve [AUC]: 0.753), -1.33 for the ALBI score (sensitivity: 0.550; specificity: 0.617; AUC: 0.539), 2.73 for the FIB-4 index (sensitivity: 0.700; specificity: 0.475; AUC: 0.550), and -0.85 for the ALBI-FIB4 score (sensitivity: 0.800; specificity: 0.467; AUC: 0.572). The cumulative risk of TEIC-induced abnormal liver enzyme levels was significantly higher for patients with ALT ≥24 IU/L (P < 0.01) and ALBI-FIB4 score ≥-0.85 (P = 0.042). Patients with a serum TEIC concentration of <30 µg/mL exhibited a similar trend, with a higher cumulative risk for patients with ALBI-FIB4 score ≥-0.85 (P = 0.058).

    Conclusion and relevance: An ALBI-FIB4 score ≥-0.85 may serve as a potential predictor for TEIC-induced abnormal liver enzyme levels in patients undergoing TDM. However, evidence supporting this threshold requires further statistical validation using a larger dataset.

    Keywords: abnormal liver enzyme levels; drug-induced liver injury; hepatic functional reserve; liver fibrosis; teicoplanin.

    Keywords:Therapeutic Drug Monitoring

    关键词:治疗药物监测

    Copyright © The Annals of pharmacotherapy. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Annals of pharmacotherapy

    缩写:ANN PHARMACOTHER

    ISSN:1060-0280

    e-ISSN:1542-6270

    IF/分区:2.3/Q3

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    The Albumin-Bilirubin-Fibrosis-4 Score for Predicting Teicoplanin-Induced Abnormal Liver Enzyme Levels in Patients Undergoing Therapeutic Drug Monitoring: A Multicentral Retrospective Cohort Study