We present a mild and direct method for the radical borylation of simple aliphatic aldehydes. By employing an enamine and a photocatalyst under light irradiation, aldehydes can be transformed effectively into alkyl boronic esters via a formal decarbonylative process. This alternative route for radical borylation synthesis can not only be applied to the transformation of primary, secondary, and tertiary aldehydes but also be adapted to other radical conversion reactions through the generated alkyl radical intermediate. Mechanistic studies indicate that 4-alkyl-1,4-dihydropyridines, formed in situ from the aldehyde and enamine, are the key intermediate for the borylation process.
The Journal of organic chemistry. 2025 Mar 11. doi: 10.1021/acs.joc.4c02705 Q13.62025
One-Pot Decarbonylative Borylation of Aliphatic Aldehydes
脂肪族醛的一锅脱羰硼化反应 翻译改进
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DOI: 10.1021/acs.joc.4c02705 PMID: 40068007
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