首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

Redox report : communications in free radical research. 2025 Dec;30(1):2475691. doi: 10.1080/13510002.2025.2475691 Q25.22024

Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway

高同型半胱氨酸通过抑制Nrf2/HO-1信号通路加重牙周炎 翻译改进

Kaiqiang Yang  1  2  3  4, Yuting Yang  1  2  3  4, Ting Long  1  2  3  4, Xiaoxue Wang  1  2  3  4, Yeke Chen  1  2  3  4, Chenjiang He  1  2  3  4, Li Li  1  2  3  4, Xinbo Yang  1  2  3  4, Meixiu Jiang  5, Yichen Hu  1  2  3, Fang Dai  1  2  3, Li Song  1  2  3

作者单位 +展开

作者单位

  • 1 Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
  • 2 JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University), Nanchang, People's Republic of China.
  • 3 The Institute of Periodontal Disease, Nanchang University, Nanchang, People's Republic of China.
  • 4 The Second Clinical Medical School, Nanchang University, Nanchang, People's Republic of China.
  • 5 Institute of Translational Medicine, Nanchang University, Nanchang, People's Republic of China.
  • DOI: 10.1080/13510002.2025.2475691 PMID: 40059399

    摘要 Ai翻译

    Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates a connection between HHcy and periodontitis; however, the underlying processes remain unknown. Herein, we explored the mechanisms by which HHcy exacerbates periodontal tissue inflammation and osteoclast formation. In an animal model of periodontitis treated with HHcy, periodontal attachment loss was aggravated, and both systemic and gingival tissue inflammation levels tended to increase; additionally, antioxidant-related proteins were suppressed and expressed at low levels, whereas oxidative damage-related protein expression increased. In RAW264.7 cells treated with LPS or LPS + Hcy, the LPS + Hcy group presented increased reactive oxygen species (ROS) fluorescence intensity, and Nrf2/HO-1 signalling pathway suppression was associated with inflammatory cytokine (TNF-α) expression. In monocyte osteoclasts treated with Rankl or Rankl + Hcy, the Rankl + Hcy group presented Nrf2/HO-1 signalling pathway suppression, an increase in osteoclast-related proteins (NFATc-1 and CTSK), and a more pronounced osteoclastic phenotype. Therefore, HHcy may exacerbate inflammation severity and osteoclast generation in periodontitis by promoting ROS production and inhibiting the Nrf2/HO-1 signalling pathway.

    Keywords: Nrf2; Periodontitis; ROS; bone loss; hyperhomocysteinaemia; inflammation; innate immunity; oxidative stress.

    Keywords:Hyperhomocysteinaemia; suppresses; Nrf2/HO-1 signalling pathway

    Copyright © Redox report : communications in free radical research. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Redox report

    缩写:REDOX REP

    ISSN:1351-0002

    e-ISSN:1743-2928

    IF/分区:5.2/Q2

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway