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Advances in medical sciences. 2025 Feb 26:S1896-1126(25)00017-3. doi: 10.1016/j.advms.2025.02.007 Q32.52024

High levels of soluble neuropilin -1 in critically ill multiple trauma/surgical patients

重症多发伤/外科患者的可溶性神经丛素-1水平较高 翻译改进

Charikleia S Vrettou  1, Chrysi Keskinidou  2, Alice G Vassiliou  2, Georgios Poupouzas  2, Edison Jahaj  2, Vassilios Issaris  2, Evangelia Theodorou  2, Asimenia Halioti  2, Vassiliki Giannopoulou  2, Nikolaos S Lotsios  2, Anastasia Kotanidou  2, Ioanna Dimopoulou  2

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作者单位

  • 1 First Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece. Electronic address: vrettou@hotmail.com.
  • 2 First Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.
  • DOI: 10.1016/j.advms.2025.02.007 PMID: 40020781

    摘要 Ai翻译

    Purpose: Critically ill trauma/surgical patients may experience excessive inflammation, immune and coagulation dysregulation, leading to multiple organ failure (MOF), carrying high mortality rates. Neuropilin-1 (NRP-1) and its soluble isoform (sNRP-1) are implicated in immune response regulation, inflammation, and vascular permeability. This study aimed to investigate the possible role of sNRP-1 in trauma/surgical patients in the intensive care unit (ICU).

    Patients and methods: This prospective observational study was conducted in a 31-bed ICU and included 81 patients, 43 of whom were trauma/surgical patients and 38 of whom were matched medical patients, comprising the control group. sNRP-1, interleukin (IL)-6, IL-8, and IL-10 levels were measured on admission to the ICU (within 48 hours).

    Results: Trauma/surgical patients had significantly higher sNRP-1 (p = 0.027), IL-6, IL-8, and IL-10 levels (p<0.05) compared to medical patients. In the entire cohort, sNRP-1 correlated positively with the international normalized ratio (INR) (p = 0.017), the activated partial thromboplastin time (p = 0.026), fibrinogen (p = 0.027), alanine aminotransferase (p = 0.024), and C-reactive protein (p = 0.004). Moreover, sNRP-1 correlated negatively with total protein (p = 0.035), albumin (p = 0.005), and platelets (p = 0.033).

    Conclusion: sNRP-1 levels were elevated in critically ill trauma/surgical patients compared to matched medical ICU patients. Further research is needed to elucidate the exact role of sNRP-1 in these patients' pathophysiology.

    Keywords: Critical Illness; Inflammation; Multiple Trauma; NRP-1 protein human.

    Keywords:soluble neuropilin -1; critically ill

    Copyright © Advances in medical sciences. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Advances in medical sciences

    缩写:ADV MED SCI-POLAND

    ISSN:1896-1126

    e-ISSN:1898-4002

    IF/分区:2.5/Q3

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    High levels of soluble neuropilin -1 in critically ill multiple trauma/surgical patients