Participation of a cysteine tetrad in the recycling mechanism of methionine sulfoxide reductase a from radiation-tolerant Deinococcus bacteria
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Methionine oxidation leads to the formation of methionine sulfoxide (MetO), which is reduced back to Met by methionine sulfoxide reductases (Msrs). The catalytic mechanism used by A-type Msr (MsrA) for MetO reduction requires a catalytic cysteine (Cys), which ... ...
