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Psychopharmacology. 2025 Feb 10. doi: 10.1007/s00213-025-06752-8 Q23.32025

Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder

现实世界中的线索暴露和情绪状态对饮酒的影响：检验酒精使用障碍的神经生物学模型 翻译改进

Lindsay R Meredith  1, Wave-Ananda BaskervilleMann  1, Carrie Lee  1, Erica N Grodin  1  2, Kate M Wassum  1  3, Lara A Ray  4  5  6

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作者单位

  • 1 Department of Psychology, University of California, Los Angeles, CA, USA.
  • 2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
  • 3 Brain Research Institute, University of California, Los Angeles, CA, USA.
  • 4 Department of Psychology, University of California, Los Angeles, CA, USA. lararay@psych.ucla.edu.
  • 5 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. lararay@psych.ucla.edu.
  • 6 Brain Research Institute, University of California, Los Angeles, CA, USA. lararay@psych.ucla.edu.

    • DOI: 10.1007/s00213-025-06752-8 PMID: 39924613

    摘要 Ai翻译

    Rationale: Two prominent neurobiological models of addiction, the allostatic and incentive-sensitization models, have guided clinical research on alcohol use disorder (AUD). While these models are often viewed in isolation, it is plausible these theories are complimentary.

    Objectives: Use naturalistic, daily diary reports to determine whether positive and negative mood states influence alcohol cue sensitivity in a clinical sample with AUD.

    Methods: This is an exploratory analysis of daily diary data collected from a non-treatment seeking sample with current AUD over two weeks. Eligible adult participants (N = 50) were enrolled in a medication trial for AUD. Each morning, participants retrospectively reported on pre-drinking mood states, alcohol cue exposure, and craving levels, and subsequent alcohol intake occurring the previous day. Multilevel models tested the singular and interactive relationships between cue exposure and mood states with craving and drinking. Within-person and between-person outcomes were assessed. Exploratory analyses examined whether individuals with withdrawal-related dysphoria were more vulnerable to mood states and cue-reactivity.

    Results: Greater cue exposure was associated with higher daily drinking levels (p = .001), but not daily alcohol craving. Higher negative mood (p < .0001) and lower positive mood (p = .012) were associated with higher daily alcohol craving, but not same-day drinking. As negative mood levels increased (p < .01) and positive mood levels decreased (p = .010), the relationship between cue exposure and same-day drinking became stronger. These findings were most pronounced among those with withdrawal-related dysphoria.

    Conclusions: Findings provided concomitant support for the allostatic model and incentive-sensitization model as determinants of alcohol craving and drinking among individuals with AUD.

    Keywords: Alcohol use disorder; Allostatic; Cue exposure; Daily diary; Incentive-sensitization; Naturalistic reporting; Negative emotionality.

    Keywords：real-world cue exposure; mood states; drinking; neurobiological models; alcohol use disorder

    关键词：现实世界线索暴露; 情绪状态; 饮酒; 神经生物学模型; 酒精使用障碍

    Copyright © Psychopharmacology. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Psychopharmacology

    缩写：PSYCHOPHARMACOLOGY

    ISSN：0033-3158

    e-ISSN：1432-2072

    IF/分区：3.3/Q2

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    Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder