Older adults with cancer are at risk of over-treatment or under-treatment, and treatment decision-making is difficult due to both the complexity of adverse aging and under-representation in clinical trials. It is recommended to perform a frailty assessment before treatment decision-making. Although the importance of radiotherapy increases in geriatric oncology, there is less evidence base information on frailty assessment in radiation oncology than in medical/surgical oncology. The present literature review analyzed the available data regarding frailty assessment tools in geriatric radiation oncology. The predictive value of geriatric assessment on survival outcomes has been shown in many cancer subtypes treated with radiotherapy. Additionally, the Geriatric-8 score is the most evidenced screening tool in frailty assessment. However, researches are ongoing on the cut-off points of geriatric screening tools and which one is the best. Prospective randomized controlled trials are required for the integration of geriatric screening tools and geriatric assessment-driven interventions into geriatric radiation oncology practice.

Keywords: Frailty; G8; Geriatric assessment; Geriatric screening tool; Radiotherapy.

Copyright © 2024. Published by Elsevier Inc.

老年人癌症患者面临过度治疗或不足治疗的风险，由于老龄化的复杂性和临床试验中的代表性不足，治疗决策变得困难。建议在制定治疗方案前进行脆弱性评估。尽管放射治疗在老年肿瘤学中的重要性增加，但关于脆弱性评估的证据基础信息少于医学/外科肿瘤学。本次文献回顾分析了有关老年放疗中脆弱性评估工具的可用数据。多项癌症亚型的研究表明，老年评估对生存结果具有预测价值。此外，Geriatric-8评分是目前最被证实的脆弱性筛查工具。然而，关于老年筛查工具的临界值以及哪个工具最佳的研究仍在进行中。为了将老年筛查工具和基于老年评估的干预措施整合到老年放疗实践中，需要前瞻性随机对照试验。

关键词： 脆弱性；G8评分；老年评估；老年筛查工具；放射治疗。

版权所有 © 2024。Elsevier Inc.出版。