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The Journal of antibiotics. 2024 May 15. doi: 10.1038/s41429-024-00737-z Q22.72025

A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

由链霉菌K22-0017产生的新型聚烯大环内酯类抗生素machidamycin生物合成基因簇及其功能分析 翻译改进

Yuta Awano  1, Ryoya Ishii  2, Yume Takahashi  1, Hayama Tsutsumi  1  3, Yoshihiro Watanabe  1  3, Masaaki Sonoda  1, Rei Hokari  1  3, Masato Iwatsuki  1  3, Yuki Inahashi  4  5

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作者单位

  • 1 Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 2 School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
  • 3 Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 4 Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. y-ina@lisci.kitasato-u.ac.jp.
  • 5 Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. y-ina@lisci.kitasato-u.ac.jp.

    • DOI: 10.1038/s41429-024-00737-z PMID: 38750248

    摘要 Ai翻译

    A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin. ... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017