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The Journal of antibiotics. 2024 May 14. doi: 10.1038/s41429-024-00736-0 Q22.72025

Quinomycins with an unusual N-methyl-3-methylsulfinyl-alanine residue from a Streptomyces sp

一种含有非常罕见的N-甲基-3-甲亚砜丙氨酸残基的链霉菌抗生素赤黄霉素类化合物 翻译改进

Anqi Wang  1, Shasha Li  1, Yuanjuan Wei  1, Guiyang Wang  1, Wenjing Shi  1, Yue Shang  1, Liyan Yu  1, Shuzhen Chen  2, Yan Li  3, Maoluo Gan  4

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作者单位

  • 1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, PR China.
  • 2 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, PR China. bjcsz@imb.pumc.edu.cn.
  • 3 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, PR China. liyan@imb.pumc.edu.cn.
  • 4 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, PR China. ganml@imb.pumc.edu.cn.

    • DOI: 10.1038/s41429-024-00736-0 PMID: 38745102

    摘要 Ai翻译

    Four new echinomycin congeners, quinomycins M-P (1-4) were isolated from the cultures of the soil-derived Streptomyces sp. CPCC205575. The planar structures were determined by comprehensive analyses of NMR and HRESIMS/MS data. The absolute configurations were elucidated by the advanced Marfey's method combined with biosynthetic gene analysis. Compounds 1-4 represent the first examples of quinomycin-type natural products with the sulfur atom at the N,S-dime... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Quinomycins with an unusual N-methyl-3-methylsulfinyl-alanine residue from a Streptomyces sp