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The Journal of antibiotics. 2024 Jul;77(7):428-435. doi: 10.1038/s41429-024-00732-4 Q22.72025

Chalcomoracin promotes apoptosis and endoplasmic reticulum stress in hepatocellular carcinoma cells

chálicomatrin通过促进凋亡和内质网应激抑制肝细胞癌的作用机制研究 翻译改进

Yongliang Cui  1, Liqin Lan  2, Jiahui Lv  1, Bixing Zhao  3, Jinfeng Kong  4, Yongping Lai  5

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作者单位

  • 1 Department of Hepatobiliary Pancreatic Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China.
  • 2 Department of Intensive Care Unit, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China.
  • 3 The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China.
  • 4 Department of Liver Disease, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China. kong0168@163.com.
  • 5 Department of Hepatobiliary Pancreatic Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China. laiyongping0809@163.com.
  • DOI: 10.1038/s41429-024-00732-4 PMID: 38724630

    摘要 Ai翻译

    Chalcomoracin (CMR), a Diels-Alder adduct obtained from mulberry leaves, demonstrated wide-spectrum anti-cancer activity. Herein, we aimed to explore the function of CMR and how it works in hepatocellular carcinoma (HCC). Human HCC cell lines Hep3B and SNU-387 were cultured and treated with various concentrations of CMR (1.5, 3, and 6 µM). Subsequently, the effects of CMR on cell viability, colony formation, apoptosis, migration, and invasion abilities we... ...点击完成人机验证后继续浏览
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    期刊名:Journal of antibiotics

    缩写:J ANTIBIOT

    ISSN:0021-8820

    e-ISSN:1881-1469

    IF/分区:2.7/Q2

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    Chalcomoracin promotes apoptosis and endoplasmic reticulum stress in hepatocellular carcinoma cells