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The Journal of antibiotics. 2024 Jul;77(7):422-427. doi: 10.1038/s41429-024-00733-3 Q22.72025

Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima

来自担子菌Favolaschia minutissima培养物的抗疟原虫马方酸衍生物 翻译改进

Somporn Palasarn  1, Kitlada Srichomthong  1, Tuksaporn Thummarukcharoen  2, Chawanee Thongpanchang  1, Masahiko Isaka  3

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作者单位

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
  • 2 National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
  • 3 National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand. isaka@biotec.or.th.
  • DOI: 10.1038/s41429-024-00733-3 PMID: 38724629

    摘要 Ai翻译

    Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 0.12 and 0.21 μM, respectively. ... ...点击完成人机验证后继续浏览
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    期刊名:Journal of antibiotics

    缩写:J ANTIBIOT

    ISSN:0021-8820

    e-ISSN:1881-1469

    IF/分区:2.7/Q2

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    Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima