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The Journal of antibiotics. 2024 Jul;77(7):412-421. doi: 10.1038/s41429-024-00724-4 Q22.72025

New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model

丝状杆菌TMPU-20A065产生新型脂糖肽类利索西菌素类似物，对鸟类分枝杆菌复合体具有体内抗菌活性 翻译改进

Akiho Yagi  1, Mayu Fujiwara  2, Mayu Sato  2, Yuzu Abe  2, Ryuji Uchida  3

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作者单位

  • 1 Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan. yagia@tohoku-mpu.ac.jp.
  • 2 Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
  • 3 Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan. uchidar@tohoku-mpu.ac.jp.

    • DOI: 10.1038/s41429-024-00724-4 PMID: 38720140

    摘要 Ai翻译

    Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5-17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model