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The Journal of antibiotics. 2024 Jun;77(6):393-396. doi: 10.1038/s41429-024-00705-7 Q22.72025

A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential

来自放线菌Allostreptomyces RD068384的多环四肽大环内酰胺:立体化学和抗真菌潜力 翻译改进

Marwa Elsbaey  1  2, Yuki Samaru  3, Engy Elekhnawy  4, Naoya Oku  3, Yasuhiro Igarashi  3

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  • 1 Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. marwaelsebay1611@mans.edu.eg.
  • 2 Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan. marwaelsebay1611@mans.edu.eg.
  • 3 Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.
  • 4 Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
  • DOI: 10.1038/s41429-024-00705-7 PMID: 38594387

    摘要 Ai翻译

    A new polycyclic tetramate macrolactam designated allostreptamide (1), together with four known congeners, were isolated from the culture extract of Allostreptomyces RD068384. The planar structure of the new compound was elucidated through interpretation of NMR and MS data. The absolute configuration was determined through ROESY and ECD analyses. The isolated compounds revealed antifungal potential against fourteen Candida albicans isolates with minimum in... ...点击完成人机验证后继续浏览
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    期刊名:Journal of antibiotics

    缩写:J ANTIBIOT

    ISSN:0021-8820

    e-ISSN:1881-1469

    IF/分区:2.7/Q2

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    A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential