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The Journal of antibiotics. 2024 May;77(5):265-271. doi: 10.1038/s41429-024-00710-w Q22.72025

New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239

由海洋来源的链霉菌KKMA-0239产生的具有抗分枝杆菌活性的新多环四肽大环内酰胺类化合物 翻译改进

Satoru Shigeno  1  2, Miyu Kadowaki  1  2, Kenichiro Nagai  2, Kanji Hosoda  1  2, Takeshi Terahara  3, Tomoyasu Nishimura  4, Naoki Hasegawa  5, Hiroshi Tomoda  6  7, Taichi Ohshiro  8  9

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作者单位

  • 1 Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 2 Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 3 Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan.
  • 4 Keio University Health Center, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  • 5 Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  • 6 Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. tomodah@pharm.kitasato-u.ac.jp.
  • 7 Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. tomodah@pharm.kitasato-u.ac.jp.
  • 8 Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. ohshirot@pharm.kitasato-u.ac.jp.
  • 9 Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. ohshirot@pharm.kitasato-u.ac.jp.

    • DOI: 10.1038/s41429-024-00710-w PMID: 38531967

    摘要 Ai翻译

    During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugamycin (3), from the culture broth of marine-derived Streptomyces sp. KKMA-0239. The relative structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Furthermore, the absolute configu... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239