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Frontiers in immunology. 2024 Feb 7:15:1331731. doi: 10.3389/fimmu.2024.1331731 Q15.92025

ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication

ISG15/USP18/STAT2是调节IFN I介导的对Dengue和Zika病毒复制控制的分子枢纽 翻译改进

Constanza Eleonora Espada  1, Edroaldo Lummertz da Rocha  1, Taissa Ricciardi-Jorge  1, Adara Aurea Dos Santos  1, Zamira Guerra Soares  1, Greicy Malaquias  1, Daniel Oliveira Patrício  1, Edgar Gonzalez Kozlova  1, Paula Fernandes Dos Santos  1, Juliano Bordignon  2, Thomas J Sanford  3, Teodoro Fajardo  3, Trevor R Sweeney  3  4, André Báfica  1, Daniel Santos Mansur  1

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作者单位

  • 1 Laboratório de Imunobiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
  • 2 Laboratório de Virologia Molecular, Instituto Carlos Chagas, Instituto Carlos Chagas (ICC)/Fiocruz-PR, Curitiba, Brazil.
  • 3 Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
  • 4 Viral Gene Expression Group, The Pirbright Institute, Guildford, United Kingdom.
  • DOI: 10.3389/fimmu.2024.1331731 PMID: 38384473

    摘要 Ai翻译

    The establishment of a virus infection is the result of the pathogen's ability to replicate in a hostile environment generated by the host's immune system. Here, we found that ISG15 restricts Dengue and Zika viruses' replication through the stabilization of its binding partner USP18. ISG15 expression was necessary to control DV replication driven by both autocrine and paracrine type one interferon (IFN-I) signaling. Moreover, USP18 competes with NS5-mediat... ...点击完成人机验证后继续浏览
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    期刊名:Frontiers in immunology

    缩写:FRONT IMMUNOL

    ISSN:1664-3224

    e-ISSN:1664-3224

    IF/分区:5.9/Q1

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    ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication