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The Journal of antibiotics. 2024 Apr;77(4):214-220. doi: 10.1038/s41429-023-00700-4 Q22.72025

Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity

红天层肽衍生物的合成及其作为两性霉素B活性增强子的生物活性评价 翻译改进

Kenichiro Nagai  1, Keisuke Kobayashi  2, Ryosuke Miyake  2, Yukino Sato  2, Reiko Seki  2, Takashi Fukuda  3, Akiho Yagi  4, Ryuji Uchida  4, Taichi Ohshiro  2, Hiroshi Tomoda  2

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作者单位

  • 1 Microbial Chemistry and Medical Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. nagaik@pharm.kitasato-u.ac.jp.
  • 2 Microbial Chemistry and Medical Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 3 Department of Fisheries, Faculty of Agriculture and Agricultural Technology and Innovation Research Institute, Kindai University, 3327-204 Nakamachi, Nara, 631-8505, Japan.
  • 4 Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.

    • DOI: 10.1038/s41429-023-00700-4 PMID: 38267575

    摘要 Ai翻译

    Nectriatide 1a, a naturally occurring cyclic tetrapeptide, has been reported to a potentiator of amphotericin B (AmB) activity. In order to elucidate its structure-activity relationships, we synthesized nectriatide derivatives with different amino acids in solution-phase synthesis and evaluated AmB-potentiating activity against Candida albicans. Among them, C-and N-terminal protected linear peptides were found to show the most potent AmB-potentiating activ... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity