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The Journal of antibiotics. 2024 Apr;77(4):238-244. doi: 10.1038/s41429-024-00703-9 Q22.72025

Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid

含有吡咯烷酸的新三肽素C类似物三肽素Cpip的前体定向生物合成及其生物活性 翻译改进

Hideki Hashizume  1, Ryuichi Sawa  2, Yumiko Kubota  2, Shinya Adachi  2, Shigeko Harada  3, Masayuki Igarashi  3

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作者单位

  • 1 Laboratory of Microbiology, Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. hashizumeh@bikaken.or.jp.
  • 2 Laboratory of Molecular Structure Analysis, Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.
  • 3 Laboratory of Microbiology, Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.

    • DOI: 10.1038/s41429-024-00703-9 PMID: 38267574

    摘要 Ai翻译

    Tripropeptin C, a non-ribosomal cyclic lipopeptide containing three proline residues, exhibits excellent efficacy in the mouse-methicillin-resistant Staphylococcus aureus septicemia model. Since tripropeptins contain L-prolyl-D-proline and, as a result, are known to form a hairpin structure in proteins, it was of interest to determine whether this substructure contributes to their antibacterial activity. In this study, prolines in tripropeptin C were repla... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid