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The Journal of antibiotics. 2024 Apr;77(4):257-263. doi: 10.1038/s41429-023-00702-2 Q22.72025

Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts

基于质谱指导从Setosphaeria rostrata培养介质的乙酸乙酯提取物中分离硫代二酮哌嗪及其对TNF-α诱导的人皮肤成纤维细胞抗皮肤老化的影响 翻译改进

Haeun Kwon  1, Hee Woon Ann  2, Sojung Park  1, Jaeyoung Kwon  3, Keunwan Park  3, Seung Mok Ryu  4, Yuanqiang Guo  5, Jae-Jin Kim  6, Joung Han Yim  7, Il-Chan Kim  7, Sang Hee Shim  8, Sullim Lee  9, Dongho Lee  10

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作者单位

  • 1 Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
  • 2 Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea.
  • 3 Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, 25451, Republic of Korea.
  • 4 Herbal Medicine Resources Center, Korea Institute of Oriental Medicine, Naju, 58245, Republic of Korea.
  • 5 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, People's Republic of China.
  • 6 Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
  • 7 Division of Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.
  • 8 Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • 9 Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea. sullimlee@gachon.ac.kr.
  • 10 Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. dongholee@korea.ac.kr.

    • DOI: 10.1038/s41429-023-00702-2 PMID: 38243062

    摘要 Ai翻译

    Using mass spectrometry (MS)-guided isolation methods, a new thiodiketopiperazine derivative (1) and exserohilone (2) were isolated from an EtOAc-extract of Setosphaeria rostrata culture medium. The chemical structure of the new compound was elucidated by MS and NMR spectroscopy, and the absolute configurations were established by the quantum mechanical calculations of electronic circular dichroism. All isolated compounds were examined for their effects on... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts