The Journal of antibiotics. 2024 Mar;77(3):170-181. doi: 10.1038/s41429-023-00697-w Q22.72025

Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis

以PRRP为中心轴的高治疗指数抗菌肽的设计、生物特性和抗菌机制翻译改进

Shuang Yu¹, Boyan Jia¹, Ying Zhang¹, Yue Yu¹, Zhihua Pei², Hongxia Ma^{3 4}

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¹ College of Animal Medicine, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, PR China.

² College of Animal Medicine, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, PR China. peizhihua1978@126.com.

³ College of Animal Medicine, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, PR China. hongxia0731001@163.com.

⁴ College of Life Sciences, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, PR China. hongxia0731001@163.com.

DOI: 10.1038/s41429-023-00697-w PMID: 38233466

摘要 Ai翻译

As the important components of biological innate immunity, antimicrobial peptides (AMPs) were found in a variety of organisms including insects, plants, animals, bacteria, fungi, etc. However, high hemolytic activity, high toxicity, and poor stability of natural AMPs hinder serious their application as therapeutic agents. To overcome these problems, in this study we use PRRP as a central axis, and peptides were designed based on the sequence template XRRXX... ...点击完成人机验证后继续浏览

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期刊名：Journal of antibiotics

缩写：J ANTIBIOT

ISSN：0021-8820

e-ISSN：1881-1469

IF/分区：2.7/Q2

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Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis

以PRRP为中心轴的高治疗指数抗菌肽的设计、生物特性和抗菌机制翻译改进

Identification, Screening and Antibacterial Mechanism Analysis of Novel Antimicrobial Peptides from Sturgeon (Acipenser ruthenus) Spermary

俄罗斯鲟鱼精巢新型抗菌肽的鉴定、筛选及其抑菌机制研究

Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes

用于单栖黄蜂毒液中抗菌α-螺旋多肽的化学和生物特性及其与模型膜相互作用的研究

Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles

银铜双金属纳米颗粒的协同抗菌机制

Antibacterial mechanism and structure-activity relationships of Bombyx mori cecropin A

家蚕 Cecropin A 的抗菌机制及构效关系研究

The Low-Alkalinity Polymyxin Derivative, AL-6, Shows High Activity Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates In Vitro and A. baumannii ATCC 19606 In Vivo: Preliminary Analysis of the Antibacterial Mechanism

低碱性多粘菌素衍生物AL-6对临床分离的多重耐药鲍曼不动杆菌体外及ATCC 19606株体内均具有较高活性：抗菌机制初步分析

[Solution structure and antibacterial mechanism of two synthetic antimicrobial peptides]

[两种合成抗菌肽的溶液结构及抗菌机制]

Purification and molecular cloning of antimicrobial peptides from Scots pine seedlings

Scots pine幼苗中抗菌肽的纯化与分子克隆

Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens

抗多重耐药金黄色葡萄球菌病原体的抗菌肽的效率

Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis

以PRRP为中心轴的高治疗指数抗菌肽的设计、生物特性和抗菌机制 翻译改进

Identification, Screening and Antibacterial Mechanism Analysis of Novel Antimicrobial Peptides from Sturgeon (Acipenser ruthenus) Spermary

俄罗斯鲟鱼精巢新型抗菌肽的鉴定、筛选及其抑菌机制研究

Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes

用于单栖黄蜂毒液中抗菌α-螺旋多肽的化学和生物特性及其与模型膜相互作用的研究

Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles

银铜双金属纳米颗粒的协同抗菌机制

Antibacterial mechanism and structure-activity relationships of Bombyx mori cecropin A

家蚕 Cecropin A 的抗菌机制及构效关系研究

The Low-Alkalinity Polymyxin Derivative, AL-6, Shows High Activity Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates In Vitro and A. baumannii ATCC 19606 In Vivo: Preliminary Analysis of the Antibacterial Mechanism

低碱性多粘菌素衍生物AL-6对临床分离的多重耐药鲍曼不动杆菌体外及ATCC 19606株体内均具有较高活性：抗菌机制初步分析

[Solution structure and antibacterial mechanism of two synthetic antimicrobial peptides]

[两种合成抗菌肽的溶液结构及抗菌机制]

Purification and molecular cloning of antimicrobial peptides from Scots pine seedlings

Scots pine幼苗中抗菌肽的纯化与分子克隆

Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens

抗多重耐药金黄色葡萄球菌病原体的抗菌肽的效率

以PRRP为中心轴的高治疗指数抗菌肽的设计、生物特性和抗菌机制翻译改进