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Multicenter Study Clinical lung cancer. 2023 Nov;24(7):e275-e281. doi: 10.1016/j.cllc.2023.06.007 Q23.32025

Non-Small Cell Lung Cancer With N1 Involvement or Skip Metastases Presents the Same Survival Outcome: Results From a Multicentric Study

N1受累或跳跃性淋巴结转移的非小细胞肺癌患者预后相同：多中心研究结果 翻译改进

Marco Chiappetta  1, Carolina Sassorossi  1, Filippo Lococo  2, Isabella Sperduti  3, Felice Mucilli  4, Paraskevas Lyberis  5, GiovanniBattista Ratto  6, Lorenzo Spaggiari  7, Filippo Gallina  8, Francesco Facciolo  8, Stefano Margaritora  1

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作者单位

  • 1 Università Cattolica del Sacro Cuore, Rome, Italy; Thoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • 2 Università Cattolica del Sacro Cuore, Rome, Italy; Thoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address: filippo.lococo@policlinicogemellli.it.
  • 3 Biostatistics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • 4 Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy.
  • 5 Department of Thoracic Surgery, University of Turin, San Giovanni Battista Hospital, Turin, Italy.
  • 6 Division of Thoracic Surgery, IRCCS AOU "San Martino" IST, Genoa, Italy.
  • 7 Thoracic Surgery Division, European Institute of Oncology, University of Milan, Milan, Italy.
  • 8 Thoracic Surgery, Regina Elena National Cancer Institute, Rome, Italy.

    • DOI: 10.1016/j.cllc.2023.06.007 PMID: 37481338

    摘要 Ai翻译

    Background: The prognostic difference among patients affected by NSCLC with hilar metastases only or mediastinal nodes metastases without hilar involvement (skip metastases) is still unclear. Aim of this study is to analyse if prognostic difference are present or if the two groups present the same survival outcome.

    Materials and methods: Data on NSCLC patients from 7 high volume centres (2004-2014) were collected and retrospectively reviewed. Histology different from adenocarcinoma(ADC) or squamous cell carcinoma(SCC), patients without data on lymphadenectomy, who underwent neoadjuvant treatment, with distant metastases or incomplete resection were excluded, selecting patients with hilar involvement or with skip metastases. Different prognostic factors such as Tstage, histology, pathological stage, nodal characteristics and adjuvant therapy administration were correlated to overall survival (OS) by the Kaplan-Meier product-limit method. The log-rank test was used to assess differences between subgroups. A multivariable Cox proportional hazard model was developed using stepwise regression to compare the prognostic power of different factors.

    Results: The final analysis was conducted on 480 adenocarcinoma/squamous cell carcinoma patients. Five-year OS (5YOS) resulted 53.9%. No significant differences in OS were detected comparing pN1 vs. pN2 patients or stage IIB vs. stage IIIA-B patients. Univariable confirmed as favourable prognostic factors young age (P<.001), T1-2 tumors (P=.030), number of resected nodes≥10 (P=.040), lymph node ratio (P=.026). Multivariable analysis confirmed as independent negative prognostic factors T≥3 (HR:1.385, 95%CI:1.037-1.851, P=.027) and age≥68 years (HR1.637, 95%CI:1.245-2.152).

    Conclusion: Patients with N1 involvement or skip metastases present a similar prognosis, suggesting that N2 involvement in these cases may be related to a direct lymphatic drainage to the mediastinal stations.

    Keywords: Adenocarcinoma; Lymph nodes; Relapse; Squamous cell carcinoma; Surgery.

    Keywords：non-small cell lung cancer; n1 involvement; skip metastases; survival outcome

    关键词：非小细胞肺癌; N1淋巴结受累; 跳跃性转移; 生存结局

    Copyright © Clinical lung cancer. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Clinical lung cancer

    缩写：CLIN LUNG CANCER

    ISSN：1525-7304

    e-ISSN：1938-0690

    IF/分区：3.3/Q2

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    Non-Small Cell Lung Cancer With N1 Involvement or Skip Metastases Presents the Same Survival Outcome: Results From a Multicentric Study