ACS omega. 2023 Feb 8;8(7):6597-6607. doi: 10.1021/acsomega.2c06992 Q24.32025

Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency

具有增强活性的第三类选择性抗沙眼衣原体化合物酰基吡唑啉翻译改进

Bin Lu^{1 2}, Qi Qiao³, Elizabeth R Park^{3 4}, Yuxuan Wang², John A Gilleran³, Matthew Pan², Daniel S Pilch², Xiang Wu¹, Jacques Y Roberge³, Huizhou Fan²

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作者单位

¹ Department of Parasitology, Central South University Xiangya Medical School, Changsha, Hunan 410013, China.

² Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.

³ Molecular Design and Synthesis Core, RUBRIC, Office for Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.

⁴ Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.

DOI: 10.1021/acsomega.2c06992 PMID: 36844602

摘要 Ai翻译

Chlamydiae are obligate intracellular Gram-negative bacteria and widespread pathogens in humans and animals. Broad-spectrum antibiotics are currently used to treat chlamydial infections. However, broad-spectrum drugs also kill beneficial bacteria. Recently, two generations of benzal acylhydrazones have been shown to selectively inhibit chlamydiae without toxicity to human cells and lactobacilli, which are dominating, beneficial bacteria in the vagina of re... ...点击完成人机验证后继续浏览

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Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency

具有增强活性的第三类选择性抗沙眼衣原体化合物酰基吡唑啉翻译改进

Design, synthesis and evaluation of diphenyl ether-based kaiso inhibitors with enhanced potency

基于联苯醚的Kaiso抑制剂的设计、合成及增效评价

Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency

基于理据的从头设计含脱氢苯丙氨酸抗生素肽及序列系统修改以增强效力

Enhanced potency of bivalent small molecule gp41 inhibitors

一种双价小分子gp41抑制剂的增强效力

Shortened insulin with enhanced in vitro potency

一种体内活性增强的胰岛素类似物

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性

An etanercept O-glycovariant with enhanced potency

一种效力增强的Etanercept O-糖链变体

Immunization in India with trivalent and monovalent oral poliovirus vaccines of enhanced potency

高效力三价和单价口服脊灰疫苗在印度的使用

Cefepime : The Last Generation or the First Enhanced-Potency Broad Spectrum Cephalosporin?

碳青霉烯类：第四代头孢菌素还是广谱增强型抗菌药物？

Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency

具有增强活性的第三类选择性抗沙眼衣原体化合物酰基吡唑啉 翻译改进

Design, synthesis and evaluation of diphenyl ether-based kaiso inhibitors with enhanced potency

基于联苯醚的Kaiso抑制剂的设计、合成及增效评价

Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency

基于理据的从头设计含脱氢苯丙氨酸抗生素肽及序列系统修改以增强效力

Enhanced potency of bivalent small molecule gp41 inhibitors

一种双价小分子gp41抑制剂的增强效力

Shortened insulin with enhanced in vitro potency

一种体内活性增强的胰岛素类似物

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性

An etanercept O-glycovariant with enhanced potency

一种效力增强的Etanercept O-糖链变体

Immunization in India with trivalent and monovalent oral poliovirus vaccines of enhanced potency

高效力三价和单价口服脊灰疫苗在印度的使用

Cefepime : The Last Generation or the First Enhanced-Potency Broad Spectrum Cephalosporin?

碳青霉烯类：第四代头孢菌素还是广谱增强型抗菌药物？

具有增强活性的第三类选择性抗沙眼衣原体化合物酰基吡唑啉翻译改进