Frontiers in microbiology. 2020 Jun 19:11:1313. doi: 10.3389/fmicb.2020.01313 Q14.52025

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性翻译改进

Cong Chen¹, Zuliang Liu¹, Liguo Liu¹, Jianmin Wang¹, Qi Jin^{1 2}

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作者单位

¹ NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

² Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

DOI: 10.3389/fmicb.2020.01313 PMID: 32636820

摘要 Ai翻译

H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, HNIgGA6, by isolating rearranged heavy- and light-chain genes from convalescent patients. The mAb disrupts viral attachment to the cellular receptor by directly interposing into the receptor binding site (RBS) and broadly neutralizing divergent H7N9 str... ...点击完成人机验证后继续浏览

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期刊名：Frontiers in microbiology

缩写：FRONT MICROBIOL

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e-ISSN：1664-302X

IF/分区：4.5/Q1

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Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性翻译改进

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

通过加热纯化FGF21活性蛋白质及基于结构设计更高效力的FGF21变异体

Correction to "Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069"

对“发现和基于结构设计强效的共价PPARγ反激动剂BAY-4931和BAY-0069”的纠正

Perspectives for the structure-based design of acetylcholinesterase reactivators

基于结构的乙酰胆碱酯酶复活剂设计展望

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design

基于结构的轻链药物设计及高活性香豆素类免疫球蛋白轻链淀粉样原纤维稳定剂的发现

Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design

基于结构设计识别高选择性食欲肽1受体拮抗剂的研究

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

基于结构的细菌RNA聚合酶抑制剂的新配体设计

Structure based design of 11β-HSD1 inhibitors

基于结构的11β-HSD1抑制剂设计

Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy

基于结构的药物设计发现乙酰胆碱酯酶特异性探针

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性 翻译改进

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

通过加热纯化FGF21活性蛋白质及基于结构设计更高效力的FGF21变异体

Correction to "Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069"

对“发现和基于结构设计强效的共价PPARγ反激动剂BAY-4931和BAY-0069”的纠正

Perspectives for the structure-based design of acetylcholinesterase reactivators

基于结构的乙酰胆碱酯酶复活剂设计展望

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design

基于结构的轻链药物设计及高活性香豆素类免疫球蛋白轻链淀粉样原纤维稳定剂的发现

Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design

基于结构设计识别高选择性食欲肽1受体拮抗剂的研究

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

基于结构的细菌RNA聚合酶抑制剂的新配体设计

Structure based design of 11β-HSD1 inhibitors

基于结构的11β-HSD1抑制剂设计

Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy

基于结构的药物设计发现乙酰胆碱酯酶特异性探针

基于结构设计增强Broad H7N9中和单抗HNIgGA6的活性翻译改进