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Chemical communications (Cambridge, England). 2022 Jul 12;58(56):7793-7796. doi: 10.1039/d2cc03106j Q24.22025

Diastereoselective palladium-catalyzed C(sp3)-H cyanomethylation of amino acid and carboxylic acid derivatives

脯氨酸和羧酸的 sp3-C 氢氰酸甲酯的对映选择性钯催化反应 翻译改进

Sumit Garai  1, Krishna Gopal Ghosh  1, Ashik Biswas  1, Sushobhan Chowdhury  2, Devarajulu Sureshkumar  1

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作者单位

  • 1 Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India. suresh@iiserkol.ac.in.
  • 2 Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, India.
  • DOI: 10.1039/d2cc03106j PMID: 35735087

    摘要 Ai翻译

    In this study, we report an efficient protocol for Pd-catalyzed methylene β-C(sp3)-H cyanomethylation of 8-aminoquinoline-directed α-amino acids using inexpensive chloroacetonitrile. Iodoacetonitrile generated in situ from chloroacetonitrile reacts with methylene C(sp3)-H bonds of α-amino acids with excellent diastereoselectivity, enabling access to a wide range of important γ-cyano-α-amino acids. Our protocol works well with different amino acid and ... ...点击完成人机验证后继续浏览
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    期刊名:Chemical communications

    缩写:CHEM COMMUN

    ISSN:1359-7345

    e-ISSN:1364-548X

    IF/分区:4.2/Q2

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    Diastereoselective palladium-catalyzed C(sp3)-H cyanomethylation of amino acid and carboxylic acid derivatives