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Movement disorders : official journal of the Movement Disorder Society. 2022 Jun;37(6):1245-1255. doi: 10.1002/mds.28988 Q17.62025

Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism

异质性帕金森病患者黑质神经黑素变化的部位选择性研究 翻译改进

Lydia Chougar  1  2  3, Emina Arsovic  2  3  4, Rahul Gaurav  2  3  5, Emma Biondetti  2  3  5, Alice Faucher  6  7, Romain Valabrègue  2  5, Nadya Pyatigorskaya  2  3  4, Gwendoline Dupont  8, François-Xavier Lejeune  5  9, Florence Cormier  5  10, Jean-Christophe Corvol  5  11, Marie Vidailhet  3  5  10, Bertrand Degos  6  7, David Grabli  5  10, Stéphane Lehéricy  2  3  4

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作者单位

  • 1 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France, Paris, France.
  • 2 ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.
  • 3 ICM, Team "Movement Investigations and Therapeutics" (MOV'IT), Paris, France.
  • 4 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France, Paris, France.
  • 5 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France.
  • 6 Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, Université PSL, Paris, France.
  • 7 Service de Neurologie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine-Saint-Denis, APHP, Bobigny, France.
  • 8 Centre hospitalier universitaire François Mitterrand, Département de Neurologie, Université de Bourgogne, Dijon, France.
  • 9 ICM, Data and Analysis Core, Paris, France.
  • 10 Clinique des mouvements anormaux, Département de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France.
  • 11 ICM, Centre d'Investigation Clinique Neurosciences, Paris, France.

    • DOI: 10.1002/mds.28988 PMID: 35347754

    摘要 Ai翻译

    Background: Neurodegeneration in the substantia nigra pars compacta (SNc) in parkinsonian syndromes may affect the nigral territories differently.

    Objective: The objective of this study was to investigate the regional selectivity of neurodegenerative changes in the SNc in patients with Parkinson's disease (PD) and atypical parkinsonism using neuromelanin-sensitive magnetic resonance imaging (MRI).

    Methods: A total of 22 healthy controls (HC), 38 patients with PD, 22 patients with progressive supranuclear palsy (PSP), 20 patients with multiple system atrophy (MSA, 13 with the parkinsonian variant, 7 with the cerebellar variant), 7 patients with dementia with Lewy body (DLB), and 4 patients with corticobasal syndrome were analyzed. volume and signal-to-noise ratio (SNR) values of the SNc were derived from neuromelanin-sensitive MRI in the whole SNc. Analysis of signal changes was performed in the sensorimotor, associative, and limbic territories of the SNc.

    Results: SNc volume and corrected volume were significantly reduced in PD, PSP, and MSA versus HC. Patients with PSP had lower volume, corrected volume, SNR, and contrast-to-noise ratio than HC and patients with PD and MSA. Patients with PSP had greater SNR reduction in the associative region than HC and patients with PD and MSA. Patients with PD had reduced SNR in the sensorimotor territory, unlike patients with PSP. Patients with MSA did not differ from patients with PD.

    Conclusions: This study provides the first MRI comparison of the topography of neuromelanin changes in parkinsonism. The spatial pattern of changes differed between PSP and synucleinopathies. These nigral topographical differences are consistent with the topography of the extranigral involvement in parkinsonian syndromes. © 2022 International Parkinson and Movement Disorder Society.

    Keywords: Parkinson's disease; multiple system atrophy; neuromelanin-sensitive imaging; progressive supranuclear palsy; substantia nigra degeneration.

    Keywords：neuromelanin changes; substantia nigra; atypical parkinsonism

    关键词：神经黑素变化; 黑质; 非典型帕金森病

    Copyright © Movement disorders : official journal of the Movement Disorder Society. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Movement disorders

    缩写：MOVEMENT DISORD

    ISSN：0885-3185

    e-ISSN：1531-8257

    IF/分区：7.6/Q1

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