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FEBS letters. 2021 Aug;595(16):2127-2146. doi: 10.1002/1873-3468.14153 Q23.02025

Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells

T细胞质膜上膜蛋白的聚合和流动性与局部脂序相互作用 翻译改进

Iztok Urbančič  1  2, Lisa Schiffelers  1, Edward Jenkins  1, Weijian Gong  1, Ana Mafalda Santos  1, Falk Schneider  1, Caitlin O'Brien-Ball  1, Mai Tuyet Vuong  1, Nicole Ashman  1, Erdinc Sezgin  1  3, Christian Eggeling  1  4  5

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作者单位

  • 1 MRC Weatherall Institute of Molecular Medicine, University of Oxford, UK.
  • 2 Jožef Stefan Institute, Ljubljana, Slovenia.
  • 3 Science for Life Laboratory, Karolinska Institutet, Solna, Sweden.
  • 4 Institute of Applied Optics and Biophysics, Friedrich-Schiller-University Jena, Germany.
  • 5 Leibniz Institute of Photonic Technology e.V., Jena, Germany.

    • DOI: 10.1002/1873-3468.14153 PMID: 34160065

    摘要 Ai翻译

    To disentangle the elusive lipid-protein interactions in T-cell activation, we investigate how externally imposed variations in mobility of key membrane proteins (T-cell receptor [TCR], kinase Lck, and phosphatase CD45) affect the local lipid order and protein colocalisation. Using spectral imaging with polarity-sensitive membrane probes in model membranes and live Jurkat T cells, we find that partial immobilisation of proteins (including TCR) by aggregati... ...点击完成人机验证后继续浏览
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    期刊名：Febs letters

    缩写：FEBS LETT

    ISSN：0014-5793

    e-ISSN：1873-3468

    IF/分区：3.0/Q2

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    Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells