Biomolecules. 2021 May 29;11(6):808. doi: 10.3390/biom11060808 Q14.82025

Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

PI3K抑制剂pictilisib通过阻断流感病毒的细胞和小鼠肺部复制发挥抗病毒作用翻译改进

Stefanie Deinhardt-Emmer^{1 2}, Laura Jäckel³, Clio Häring², Sarah Böttcher², Janine J Wilden³, Brigitte Glück², Regine Heller⁴, Michaela Schmidtke², Mirijam Koch¹, Bettina Löffler¹, Stephan Ludwig³, Christina Ehrhardt²

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作者单位

¹ Institute of Medical Microbiology, Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany.

² Section of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knoell-Str. 2, D-07745 Jena, Germany.

³ Institute of Virology Muenster, Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms-University, D-48149 Muenster, Germany.

⁴ Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knoell-Str. 2, D-07745 Jena, Germany.

DOI: 10.3390/biom11060808 PMID: 34072389

摘要 Ai翻译

Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic strains against the currently licensed antiviral medications points to the urgent need for new and amply available anti-influenza drugs. Interestingly, the virus-supportive function of the cellular phosphatidyl... ...点击完成人机验证后继续浏览

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Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

PI3K抑制剂pictilisib通过阻断流感病毒的细胞和小鼠肺部复制发挥抗病毒作用翻译改进

Studies on the propagation of PR8 influenza virus in the developing chick embryo

PR8流感病毒在鸡胚发育不同阶段的生长规律研究

INTERFERENCE OF INACTIVE VIRUS WITH THE PROPAGATION OF VIRUS OF INFLUENZA

inactive病毒对流感病毒传播的干扰作用

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

流感病毒增殖、固有宿主防御和肺损伤中的凋亡信号转导

ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells

ABT-737和pictilisib协同增强pitavastatin诱导的卵巢癌细胞凋亡

Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging

用于基质辅助激光解析电离成像的磷脂酰肌醇3-激酶抑制剂 pictilisib（GDC-0941）和 GNE-317 在 U87 和 GS2 原位胶质母细胞瘤模型中的分布研究

[A screening method for anti-influenzal drugs; influenza virus propagation inhibition test (author's transl)]

[抗流感病毒药物筛选方法-流感病毒培养抑制试验]

Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity

鞘氨醇-1-磷酸代谢酶调控流感病毒的增殖和病毒细胞毒效应

Distinct propagation efficiencies of H5N1 influenza virus Thai isolates in newly established murine respiratory region-derived cell clones

来自泰国的H5N1流感病毒分离株在新建立的小鼠呼吸系统区域衍生细胞克隆中不同的传播效率

Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

PI3K抑制剂pictilisib通过阻断流感病毒的细胞和小鼠肺部复制发挥抗病毒作用 翻译改进

Studies on the propagation of PR8 influenza virus in the developing chick embryo

PR8流感病毒在鸡胚发育不同阶段的生长规律研究

INTERFERENCE OF INACTIVE VIRUS WITH THE PROPAGATION OF VIRUS OF INFLUENZA

inactive病毒对流感病毒传播的干扰作用

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

流感病毒增殖、固有宿主防御和肺损伤中的凋亡信号转导

ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells

ABT-737和pictilisib协同增强pitavastatin诱导的卵巢癌细胞凋亡

Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging

用于基质辅助激光解析电离成像的磷脂酰肌醇3-激酶抑制剂 pictilisib（GDC-0941）和 GNE-317 在 U87 和 GS2 原位胶质母细胞瘤模型中的分布研究

[A screening method for anti-influenzal drugs; influenza virus propagation inhibition test (author's transl)]

[抗流感病毒药物筛选方法-流感病毒培养抑制试验]

Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity

鞘氨醇-1-磷酸代谢酶调控流感病毒的增殖和病毒细胞毒效应

Distinct propagation efficiencies of H5N1 influenza virus Thai isolates in newly established murine respiratory region-derived cell clones

来自泰国的H5N1流感病毒分离株在新建立的小鼠呼吸系统区域衍生细胞克隆中不同的传播效率

PI3K抑制剂pictilisib通过阻断流感病毒的细胞和小鼠肺部复制发挥抗病毒作用翻译改进