European journal of pharmacology. 2021 Mar 5:894:173814. doi: 10.1016/j.ejphar.2020.173814 Q14.72025

Enhanced targeting of 3D pancreatic cancer spheroids by aptamer-conjugated polymeric micelles with deep tumor penetration

一种新型适配体聚合物胶束的制备及其在三维胰腺癌类器官中的高效递送研究翻译改进

Libing Tian¹, Rui Pei¹, Lijuan Zhong¹, Yuchao Ji¹, Danhua Zhou², Shufeng Zhou³

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¹ Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.

² Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China. Electronic address: zhoudh@hqu.edu.cn.

³ Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China. Electronic address: szhou@hqu.edu.cn.

DOI: 10.1016/j.ejphar.2020.173814 PMID: 33352182

摘要 Ai翻译

Pancreatic cancer is a high degree malignant tumor which makes its diagnosis and treatment highly critical. The effect of conventional chemotherapy for pancreatic cancer is quite poor due to the low accumulation of the chemotherapeutic drugs at the tumor site. Therefore, enhancing the targeting efficiency and accumulation of the drug carrier at tumor site with subsequent release of drug within the effective time period is one of the key factors for success... ...点击完成人机验证后继续浏览

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期刊名：European journal of pharmacology

缩写：EUR J PHARMACOL

ISSN：0014-2999

e-ISSN：1879-0712

IF/分区：4.7/Q1

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Enhanced targeting of 3D pancreatic cancer spheroids by aptamer-conjugated polymeric micelles with deep tumor penetration

一种新型适配体聚合物胶束的制备及其在三维胰腺癌类器官中的高效递送研究翻译改进

Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

表面修饰技术在纳米医学深层肿瘤渗透中的应用

Erratum to: Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer

题为“同质性胰腺癌类器官模拟循环肿瘤细胞簇和大转移灶的生长模式：表现出内层的异质性和坑状结构”的勘误表

Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy

酶触发尺寸可变纳米系统用于肿瘤深度穿透及氢疗

A homologous-targeting "nanoconverter" with variable size for deep tumor penetration and immunotherapy

一种可变大小的同源靶向“纳米转换器”，用于深层肿瘤渗透和免疫治疗

Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers

前列腺特异性膜抗原靶向聚合物纳米载药体系的深层肿瘤穿透作用

Reversible chemoresistance of pancreatic cancer grown as spheroids

以类器官形式培养的胰腺癌的可逆性化学耐药性

A Novel Strategy through Combining iRGD Peptide with Tumor-Microenvironment-Responsive and Multistage Nanoparticles for Deep Tumor Penetration

一种通过结合iRGD肽与肿瘤微环境响应型和多级纳米颗粒实现深部肿瘤渗透的新策略

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

基质金属蛋白酶敏感的尺寸可减小的纳米颗粒用于肿瘤深部渗透和pH控释阿霉素

Enhanced targeting of 3D pancreatic cancer spheroids by aptamer-conjugated polymeric micelles with deep tumor penetration

一种新型适配体聚合物胶束的制备及其在三维胰腺癌类器官中的高效递送研究 翻译改进

Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

表面修饰技术在纳米医学深层肿瘤渗透中的应用

Erratum to: Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer

题为“同质性胰腺癌类器官模拟循环肿瘤细胞簇和大转移灶的生长模式：表现出内层的异质性和坑状结构”的勘误表

Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy

酶触发尺寸可变纳米系统用于肿瘤深度穿透及氢疗

A homologous-targeting "nanoconverter" with variable size for deep tumor penetration and immunotherapy

一种可变大小的同源靶向“纳米转换器”，用于深层肿瘤渗透和免疫治疗

Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers

前列腺特异性膜抗原靶向聚合物纳米载药体系的深层肿瘤穿透作用

Reversible chemoresistance of pancreatic cancer grown as spheroids

以类器官形式培养的胰腺癌的可逆性化学耐药性

A Novel Strategy through Combining iRGD Peptide with Tumor-Microenvironment-Responsive and Multistage Nanoparticles for Deep Tumor Penetration

一种通过结合iRGD肽与肿瘤微环境响应型和多级纳米颗粒实现深部肿瘤渗透的新策略

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

基质金属蛋白酶敏感的尺寸可减小的纳米颗粒用于肿瘤深部渗透和pH控释阿霉素

一种新型适配体聚合物胶束的制备及其在三维胰腺癌类器官中的高效递送研究翻译改进