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Randomized Controlled Trial The international journal of behavioral nutrition and physical activity. 2020 Dec 14;17(1):152. doi: 10.1186/s12966-020-01057-9 Q15.52024

Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity: a randomized crossover trial

久坐期间连续运动与间歇性活跃打断对肥胖成年人餐后血糖，胰岛素和甘油三酯的联合影响：一项随机交叉试验 翻译改进

Michael J Wheeler  1  2  3, Daniel J Green  4, Ester Cerin  5  6  7, Kathryn A Ellis  8, Ilkka Heinonen  4  9  10, Jaye Lewis  4, Louise H Naylor  4, Neale Cohen  5, Robyn Larsen  5, Paddy C Dempsey  5  11  12, Bronwyn A Kingwell  5, Neville Owen  5  13, David W Dunstan  4  5  6

作者单位 +展开

作者单位

  • 1 Cardiovascular Research Group, School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Australia. michael.wheeler@baker.edu.au.
  • 2 Baker Heart and Diabetes Institute, 99 Commercial Rd, Melbourne, Victoria, 3004, Australia. michael.wheeler@baker.edu.au.
  • 3 Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia. michael.wheeler@baker.edu.au.
  • 4 Cardiovascular Research Group, School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Australia.
  • 5 Baker Heart and Diabetes Institute, 99 Commercial Rd, Melbourne, Victoria, 3004, Australia.
  • 6 Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
  • 7 School of Public Health, The University of Hong Kong, Hong Kong, China.
  • 8 Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.
  • 9 Turku PET Centre, University of Turku, Turku, Finland.
  • 10 Rydberg Laboratory of Applied Sciences, ETN, Halmstad University, Halmstad, Sweden.
  • 11 MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • 12 Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • 13 Centre for Urban Transitions, Swinburne University of Technology, Hawthorn, Australia.

    • DOI: 10.1186/s12966-020-01057-9 PMID: 33308235

    摘要 中英对照阅读

    Background: Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides.

    Methods: Sedentary adults who were overweight to obese (n = 67; mean age 67 yr SD ± 7; BMI 31.2 kg∙m- 2 SD ± 4.1), completed three conditions: SIT: uninterrupted sitting (8-h, control); EX+SIT: sitting (1-h), moderate-intensity walking (30-min), uninterrupted sitting (6.5-h); EX+BR: sitting (1-h), moderate-intensity walking (30- min), sitting interrupted every 30-min with 3-min of light-intensity walking (6.5 h). Participants consumed standardized breakfast and lunch meals and blood was sampled at 13 time-points.

    Results: When compared to SIT, EX+SIT increased total area under the curve (tAUC) for glucose by 2% [0.1-4.1%] and EX+BR by 3% [0.6-4.7%] (all p < 0.05). Compared to SIT, EX+SIT reduced insulin and insulin:glucose ratio tAUC by 18% [11-22%] and 21% [8-33%], respectively; and EX+BR reduced values by 25% [19-31%] and 28% [15-38%], respectively (all p < 0.001 vs SIT, all p < 0.05 EX+SIT-vs-EX+BR). Compared to SIT, EX+BR reduced triglyceride tAUC by 6% [1-10%] (p = 0.01 vs SIT), and compared to EX+SIT, EX+BR reduced this value by 5% [0.1-8.8%] (p = 0.047 vs EX+SIT). The magnitude of reduction in insulin tAUC from SIT-to-EX+BR was greater in those with increased basal insulin resistance. No reduction in triglyceride tAUC from SIT-to-EX+BR was apparent in those with high fasting triglycerides.

    Conclusions: Additional reductions in postprandial insulin-glucose dynamics and triglycerides may be achieved by combining exercise with breaks in sitting. Relative to uninterrupted sitting, this strategy may reduce postprandial insulin more in those with high basal insulin resistance, but those with high fasting triglycerides may be resistant to such intervention-induced reductions in triglycerides.

    Trial registration: Australia New Zealand Clinical Trials Registry ( ACTRN12614000737639 ).

    Keywords: Exercise; Glucose; Insulin resistance; Lipids; Postprandial; Sedentary behavior.

    Keywords：continuous exercise; prolonged sitting; postprandial glucose

    背景：餐后葡萄糖、胰岛素和甘油三酯代谢会因久坐而受损，但运动会增强。本研究旨在评估连续运动对餐后血糖、胰岛素和甘油三酯的影响，包括间歇性主动中断和非间歇性主动中断。方法：超重至肥胖的久坐成人（n=67；平均年龄67岁SD±7；BMI 31.2 kg∙m-2 SD±4.1），完成三个条件：SIT：不间断坐姿（8小时，对照组）；EX+SIT：坐姿（1小时），中等强度步行（30分钟），不间断坐姿（6.5小时）；EX+BR：坐着（1小时），中等强度步行（30分钟），每30分钟休息一次，然后进行3分钟的轻度步行（6.5小时）。参与者食用标准化的早餐和午餐，并在13个时间点采集血液样本。结果：与SIT相比，EX+SIT使葡萄糖的曲线下总面积（tAUC）增加了2%[0.1-4.1%]，EX+BR增加了3%[0.6-4.7%]（均p<0.05）。与SIT相比，EX+SIT分别将胰岛素和胰岛素：葡萄糖比tAUC降低了18%[11-22%]和21%[8-33%]；EX+BR的值分别降低了25%[19-31%]和28%[15-38%]（与SIT相比，所有p<0.001，与EX+BR相比，所有p<0.05）。与SIT相比，EX+BR将甘油三酯tAUC降低了6%[1-10%]（与SIT比较p=0.01），与EX+SIT相比，EX+PR将该值降低了5%[0.1-8.8%]（与EX+SITE比较p=0.047）。在基础胰岛素抵抗增加的患者中，胰岛素tAUC从SIT到EX+BR的减少幅度更大。在空腹甘油三酯水平较高的人群中，甘油三酯tAUC从SIT到EX+BR没有明显降低。结论：通过将运动与坐着休息相结合，可以进一步降低餐后胰岛素葡萄糖动力学和甘油三酯。相对于不间断的坐姿，这种策略可能会在基础胰岛素抵抗较高的人中更多地减少餐后胰岛素，但那些空腹甘油三酯较高的人可能对这种干预诱导的甘油三酯减少有抵抗力。试验注册：澳大利亚新西兰临床试验注册中心（ACTRN12614000737639）。关键词：运动；葡萄糖；胰岛素抵抗；脂质；餐后；久坐不动的行为。

    关键词：持续运动; 间歇性主动中断; 长时间久坐; 餐后血糖

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    期刊名：International journal of behavioral nutrition and physical activity

    缩写：INT J BEHAV NUTR PHY

    ISSN：N/A

    e-ISSN：1479-5868

    IF/分区：5.5/Q1

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    Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity: a randomized crossover trial