首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

Breast cancer research and treatment. 2020 Dec;184(3):901-914. doi: 10.1007/s10549-020-05901-1 Q23.02024

Pre-diagnostic allostatic load and health-related quality of life in a cohort of Black breast cancer survivors

黑色素瘤幸存者诊断前的异质性负荷和与健康相关的生活质量 翻译改进

Cathleen Y Xing  1, Michelle Doose  1  2, Bo Qin  2  3, Yong Lin  1  2, Tiffany L Carson  4, Jesse J Plascak  1  2, Kitaw Demissie  5, Chi-Chen Hong  6, Elisa V Bandera  1  2  3, Adana A M Llanos  7  8

作者单位 +展开

作者单位

  • 1 Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
  • 2 Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • 3 Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • 4 Division of Preventive Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
  • 5 Department of Epidemiology and Biostatistics, SUNY Downstate Health Sciences University School of Public Health, Brooklyn, NY, USA.
  • 6 Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • 7 Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. Adana.Llanos@Rutgers.edu.
  • 8 Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. Adana.Llanos@Rutgers.edu.
  • DOI: 10.1007/s10549-020-05901-1 PMID: 32914357

    摘要 Ai翻译

    Purpose: To determine the association of pre-diagnostic allostatic load (AL) with health-related quality of life (HRQOL) among Black women with breast cancer.

    Methods: In a sample of 409 Black women with non-metastatic breast cancer enrolled in the Women's Circle of Health Follow-Up Study (WCHFS), two pre-diagnostic AL measures were estimated using medical records data from up to 12 months prior to breast cancer diagnosis: AL-lipid/metabolic profile-based measure and AL-inflammatory profile-based measure. HRQOL was assessed approximately 24 months post diagnosis, using the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) instrument, including 5 subscale scores [presented by physical well-being (PWB), social & family well-being (SFWB), emotional well-being (EWB), functional well-being (FWB), and breast cancer-specific scale (BCS)] and 3 derived total scores [presented by trial outcome index (TOI), Functional Assessment of Cancer Therapy-General (FACT-G) and FACT-B]. We used multivariable logistic regression models, using dichotomized AL scores (lower AL: 0-3 points, higher AL: 4-8 points), to assess the associations between the two pre-diagnostic AL measures and HRQOL.

    Results: Higher pre-diagnostic AL was associated with poorer FWB and lower FACT-G, but these associations were statistically significant for the AL-inflammatory profile-based measure (FWB: OR 1.63, 95% CI 1.04, 2.56; FACT-G: OR 1.62, 95% CI 1.04, 2.54), but not the AL-lipid/metabolic profile-based measure (FWB: OR 1.45, 95% CI 0.81, 2.59; FACT-G: OR 1.33, 95% CI 0.75, 2.37).

    Conclusion: These findings suggest that higher AL, particularly when measured using the inflammatory profile-based measure, was associated with poorer HRQOL, namely FWB and FACT-G, among Black breast cancer survivors.

    Keywords: Allostatic load; Black women; Breast cancer survivorship; Health-related quality of life; Longitudinal study.

    Keywords:health-related quality of life; Black breast cancer survivors

    Copyright © Breast cancer research and treatment. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Breast cancer research and treatment

    缩写:BREAST CANCER RES TR

    ISSN:0167-6806

    e-ISSN:1573-7217

    IF/分区:3.0/Q2

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Pre-diagnostic allostatic load and health-related quality of life in a cohort of Black breast cancer survivors