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Cell reports. 2020 Jun 9;31(10):107752. doi: 10.1016/j.celrep.2020.107752 Q17.52024

Heterogeneous Habenular Neuronal Ensembles during Selection of Defensive Behaviors

在选择防御行为期间异质中脑habenula神经元群体的活动 翻译改进

Salvatore Lecca  1, Vijay M K Namboodiri  2, Leonardo Restivo  3, Nicolas Gervasi  4, Giuliano Pillolla  5, Garret D Stuber  2, Manuel Mameli  6

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作者单位

  • 1 The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland. Electronic address: salvatore.lecca@unil.ch.
  • 2 Center for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
  • 3 The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland.
  • 4 College de France, INSERM, 75005 Paris, France.
  • 5 The University of Cagliari, 09042 Cagliari, Italy.
  • 6 The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland; INSERM, UMR-S 839, 75005 Paris, France. Electronic address: manuel.mameli@unil.ch.

    • DOI: 10.1016/j.celrep.2020.107752 PMID: 32521277

    摘要 Ai翻译

    Optimal selection of threat-driven defensive behaviors is paramount to an animal's survival. The lateral habenula (LHb) is a key neuronal hub coordinating behavioral responses to aversive stimuli. Yet, how individual LHb neurons represent defensive behaviors in response to threats remains unknown. Here, we show that in mice, a visual threat promotes distinct defensive behaviors, namely runaway (escape) and action-locking (immobile-like). Fiber photometry of bulk LHb neuronal activity in behaving animals reveals an increase and a decrease in calcium signal time-locked with runaway and action-locking, respectively. Imaging single-cell calcium dynamics across distinct threat-driven behaviors identify independently active LHb neuronal clusters. These clusters participate during specific time epochs of defensive behaviors. Decoding analysis of this neuronal activity reveals that some LHb clusters either predict the upcoming selection of the defensive action or represent the selected action. Thus, heterogeneous neuronal clusters in LHb predict or reflect the selection of distinct threat-driven defensive behaviors.

    Keywords: calcium imaging; cluster analysis; defensive behaviors; lateral habenula.

    Keywords：defensive behaviors

    关键词：防御行为

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    期刊名：Cell reports

    缩写：CELL REP

    ISSN：2211-1247

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    IF/分区：7.5/Q1

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